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引用次数: 0
摘要
对从美国大烟山国家公园采集的一种白蛇舌草（Ageratina altissima (L.) King & H. Rob.）病毒进行的全基因组测序发现，该病毒具有类似于伞形病毒的四核苷酸组织。ORFs1和2可能通过-1核糖体框架转换机制翻译成单个多肽，在病毒复制中发挥作用，而3′近端和广泛重叠的ORFs3和4则编码参与宿主体内长距离运输和细胞间移动的蛋白质。序列比较和系统进化分析表明，该病毒是一种以前未被描述的伞形病毒属（Tombusviridae 科）成员，我们建议将其命名为 "白蛇舌草病毒 A"（WSVA）。此外，我们还发现了它可能的辅助病毒--一种推定的 Luteovirus 属新成员，并对其特征进行了初步鉴定。
Complete genome sequence of an umbravirus from white snakeroot (Ageratina altissima)
Complete genome sequencing of a virus from a white snakeroot plant (Ageratina altissima (L.) King & H. Rob.) collected in the Great Smoky Mountains National Park, USA, revealed a quadricistronic organization resembling that of umbraviruses. ORFs 1 and 2 are putatively translated via a −1 ribosomal frameshift mechanism as a single polypeptide with a role in viral replication, whereas the 3′-proximal and extensively overlapping ORFs 3 and 4 code for proteins involved in long distance trafficing and cell-to-cell movement within the host. Sequence comparisons and phylogenetic analysis strongly suggested that this virus is a previously undescribed member of the genus Umbravirus (family Tombusviridae), for which the name “white snakeroot virus A” (WSVA) is proposed. In addition, we identified and initiated characterization of its possible helper virus, a putative new member of the genus Luteovirus.
期刊介绍：
Archives of Virology publishes original contributions from all branches of research on viruses, virus-like agents, and virus infections of humans, animals, plants, insects, and bacteria. Coverage spans a broad spectrum of topics, from descriptions of newly discovered viruses, to studies of virus structure, composition, and genetics, to studies of virus interactions with host cells, organisms and populations. Studies employ molecular biologic, molecular genetics, and current immunologic and epidemiologic approaches. Contents include studies on the molecular pathogenesis, pathophysiology, and genetics of virus infections in individual hosts, and studies on the molecular epidemiology of virus infections in populations. Also included are studies involving applied research such as diagnostic technology development, monoclonal antibody panel development, vaccine development, and antiviral drug development.Archives of Virology wishes to publish obituaries of recently deceased well-known virologists and leading figures in virology.
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