α1-ANTITRYPSIN - 在宫内节育器使用者子宫液中的复合物和非活性化作用

IF 3.5 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Acta Obstetricia et Gynecologica Scandinavica Pub Date : 2024-09-12 DOI:10.1111/j.1600-0412.1981.tb00019.x

Bertil Casslén, Kjell Ohlsson

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引用次数: 0

摘要

研究了两组正常妇女子宫液中 α1-抗胰蛋白酶（α1-AT）的电泳均匀性；一组是使用宫内节育器的妇女，另一组是未使用宫内节育器的妇女。在非使用者体内，α1-AT 以游离和活性形式存在。在使用宫内节育器的妇女中，有一部分被粒细胞弹性蛋白酶和中性蛋白酶复合。另一部分具有与原生抑制剂相同的电泳迁移率，但根据胰蛋白酶抑制研究的结果，它没有活性。这可能解释了为什么在一些宫内节育器使用者的样本中发现了弹性蛋白酶活性和非络合α1-AT。结论是，宫内节育器使用者的宫腔液即使有蛋白酶抑制潜能，也是微乎其微的。子宫腔中粒细胞蛋白酶的非抑制性活性可能会影响子宫内膜的止血。

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α1‐ANTITRYPSIN — COMPLEXATION AND INACTIVATION IN THE UTERINE FLUID OF IUD‐USERS

Electrophoretic homogeneity of α1‐antitrypsin (α1‐AT) was studied in the uterine fluid from two groups of normal women; one group was comprised of IUD‐users, the other on non‐users. α1‐AT was found in its free and active form in non‐users. In IUD‐users, one fraction was complexed by granulocyte elastase and neutral proteinase. The other fraction had the same electrophoretic mobility as the native inhibitor, but was inactive, as determined from trypsin inhibition studies. This may explain the finding of elastase activity together with non‐complexed α1‐AT in some samples from IUD‐users. It is concluded that uterine fluid in IUD‐users possesses a minimal, if any, proteinase inhibiting potential. Non‐inhibited activity of granulocyte proteinases in the uterine cavity may incluence hemostasis of the endometrium.

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来源期刊

Acta Obstetricia et Gynecologica Scandinavica 医学-妇产科学

CiteScore

8.00

自引率

4.70%

发文量

180

审稿时长

3-6 weeks

期刊介绍： Published monthly, Acta Obstetricia et Gynecologica Scandinavica is an international journal dedicated to providing the very latest information on the results of both clinical, basic and translational research work related to all aspects of women’s health from around the globe. The journal regularly publishes commentaries, reviews, and original articles on a wide variety of topics including: gynecology, pregnancy, birth, female urology, gynecologic oncology, fertility and reproductive biology.