服用避孕类固醇的妇女的尿胆汁酸

IF 3.5 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Acta Obstetricia et Gynecologica Scandinavica Pub Date : 2024-09-12 DOI:10.1111/j.1600-0412.1981.tb00032.x

Peter A. Thomassen

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引用次数: 0

摘要

通过气相色谱-质谱法测定了一种商用避孕药物治疗前和治疗期间 24 小时尿液标本中 25 种不同胆汁酸的含量。在 4 名健康女性的治疗过程中，胆汁酸的排泄模式和个体含量均未发生任何变化。一名曾有反复妊娠胆汁淤积病史的妇女在因全身瘙痒而停止服用避孕药的前一天，S-ALAT 水平和尿中胆汁酸的总量略有上升。另一名患者在每天服用 10 毫克戊酸雌二醇一年后，尿胆汁酸水平趋于正常。

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URINARY BILE ACIDS IN WOMEN TREATED WITH CONTRACEPTIVE STEROIDS

Twenty‐five different bile acids were determined by gas chromatography‐mass spectrometry in 24 hour urine specimens before and during treatment with a commercial contraceptive drug. Neither excretion pattern nor individual amounts of bile acids showed any change during treatment of 4 healthy women. One woman with a history of recurrent cholestasis of pregnancy showed a slight increase in the levels of S‐ALAT and total amount of urinary bile acids one day before she stopped taking the pill because of generalized itching. Another patient had a normal pattern of urinary bile acids after one year with a daily intake of 10 mg of estradiol valerate.

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来源期刊

Acta Obstetricia et Gynecologica Scandinavica 医学-妇产科学

CiteScore

8.00

自引率

4.70%

发文量

180

审稿时长

3-6 weeks

期刊介绍： Published monthly, Acta Obstetricia et Gynecologica Scandinavica is an international journal dedicated to providing the very latest information on the results of both clinical, basic and translational research work related to all aspects of women’s health from around the globe. The journal regularly publishes commentaries, reviews, and original articles on a wide variety of topics including: gynecology, pregnancy, birth, female urology, gynecologic oncology, fertility and reproductive biology.