海洋细菌素:消除抗生素耐药性的进化金矿

IF 4.9 2区 医学 Q1 CHEMISTRY, MEDICINAL
Marine Drugs Pub Date : 2024-08-28 DOI:10.3390/md22090388
Piyush Baindara, Roy Dinata, Santi M. Mandal
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引用次数: 0

摘要

耐药性的快速演变是 21 世纪最大的健康问题之一。寻找新的治疗策略或候选药物来解决目前的多重耐药性发展问题,形势十分严峻。海洋环境是地球上最重要的自然生态系统之一,其中大部分尚未被开发,尤其是微生物。人们已从各种海洋生物中获得了多种生物活性化合物,但海洋细菌产生的细菌素仍未得到充分开发。由于海洋细菌群落面临不同的环境压力,它们的生物活性化合物经常发生不同的适应性变化,从而赋予它们不同的形状和功能,使它们有别于陆生细菌群落。细菌产生的核糖体合成和翻译后修饰肽(RiPPs)被称为细菌素,由于其结构多样,具有多种潜在生物活性,是传统抗生素的替代品之一。此外,海洋生物的肠道微生物群也是具有良好活性的新型细菌素的主要来源,但这一来源在很大程度上尚未被开发。海洋细菌群落中的新型细菌素很有可能成为对抗抗生素耐药性的有效候选物质,尤其是在抗生素耐药性疾病的压力日益增大以及工业界对创新疗法的渴望的情况下。本综述概述了已知的、具有充分特征的海洋细菌素、其进化方面、面临的挑战,以及存在于各种海洋生态系统中的海洋细菌群落中尚未开发的新型细菌素的巨大可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Marine Bacteriocins: An Evolutionary Gold Mine to Payoff Antibiotic Resistance
The rapid evolution of drug resistance is one of the greatest health issues of the 21st century. There is an alarming situation to find new therapeutic strategies or candidate drugs to tackle ongoing multi-drug resistance development. The marine environment is one of the prime natural ecosystems on Earth, the majority of which is still unexplored, especially when it comes to the microbes. A wide variety of bioactive compounds have been obtained from a varied range of marine organisms; however, marine bacteria-produced bacteriocins are still undermined. Owing to the distinct environmental stresses that marine bacterial communities encounter, their bioactive compounds frequently undergo distinct adaptations that confer on them a variety of shapes and functions, setting them apart from their terrestrial counterparts. Bacterially produced ribosomally synthesized and posttranslationally modified peptides (RiPPs), known as bacteriocins, are one of the special interests to be considered as an alternative to conventional antibiotics because of their variety in structure and diverse potential biological activities. Additionally, the gut microbiome of marine creatures are a largely unexplored source of new bacteriocins with promising activities. There is a huge possibility of novel bacteriocins from marine bacterial communities that might come out as efficient candidates to fight against antibiotic resistance, especially in light of the growing pressure from antibiotic-resistant diseases and industrial desire for innovative treatments. The present review summarizes known and fully characterized marine bacteriocins, their evolutionary aspects, challenges, and the huge possibilities of unexplored novel bacteriocins from marine bacterial communities present in diverse marine ecosystems.
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来源期刊
Marine Drugs
Marine Drugs 医学-医药化学
CiteScore
9.60
自引率
14.80%
发文量
671
审稿时长
1 months
期刊介绍: Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.
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