褐藻糖胶的抗炎作用可抑制脂多糖诱发的小鼠炎症

IF 4.9 2区医学 Q1 CHEMISTRY, MEDICINAL

Marine Drugs Pub Date : 2024-09-02 DOI:10.3390/md22090401

Wei Zhang, Peter C. W. Lee, Jun-O Jin

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引用次数: 0

摘要

海藻提取物，尤其是褐藻糖胶，以其免疫调节能力而闻名。在本研究中，我们从一种常见于亚洲沿海地区的海藻（Costaria costata）中提取了褐藻糖胶，并研究了其抗炎效果。我们采用酒精萃取法从干燥的木贼（FCC）中提取褐藻糖胶，萃取率为 4.5 ± 0.21%。提取的褐藻糖胶中碳水化合物比例最高，此外还有硫酸盐和尿酸。研究人员使用骨髓树突状细胞（BMDCs）检验了 FCC 的免疫调节作用。经 FCC 预处理后，脂多糖（LPS）诱导的共刺激分子和主要组织相容性复合物的上调呈剂量依赖性下降。此外，催化纤维素还能防止 LPS 诱导的 BMDCs 发生形态学变化。此外，用 FCC 处理 LPS 诱导的 BMDCs 还能抑制促炎细胞因子的分泌。在 C57BL/6 小鼠中，口服 FCC 可抑制 LPS 诱导的肺部炎症，减少支气管肺泡灌洗液中促炎细胞因子的分泌。最后，服用 FCC 还能抑制 LPS 诱导的败血症。因此，基于所观察到的抗炎作用，FCC 可被开发为一种保健品。

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Anti-Inflammatory Effect of Fucoidan from Costaria costata Inhibited Lipopolysaccharide-Induced Inflammation in Mice

Seaweed extracts, especially fucoidan, are well known for their immune-modulating abilities. In this current study, we extracted fucoidan from Costaria costata, a seaweed commonly found in coastal Asia, and examined its anti-inflammatory effect. Fucoidan was extracted from dried C. costata (FCC) using an alcohol extraction method at an extraction rate of 4.5 ± 0.21%. The extracted FCC comprised the highest proportion of carbohydrates, along with sulfate and uronic acid. The immune regulatory effect of FCC was examined using bone marrow-derived dendritic cells (BMDCs). Pretreatment with FCC dose-dependently decreased the lipopolysaccharide (LPS)-induced upregulation of co-stimulatory molecules and major histocompatibility complex. In addition, FCC prevented morphological changes in LPS-induced BMDCs. Moreover, treatment of LPS-induced BMDCs with FCC suppressed the secretion of pro-inflammatory cytokines. In C57BL/6 mice, oral administration of FCC suppressed LPS-induced lung inflammation, reducing the secretion of pro-inflammatory cytokines in the bronchoalveolar lavage fluid. Finally, the administration of FCC suppressed LPS-induced sepsis. Therefore, FCC could be developed as a health supplement based on the observed anti-inflammatory effects.

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.