红树林内生真菌 Xylaria arbuscula QYF 的细胞色素和多酮类化合物

IF 4.9 2区医学 Q1 CHEMISTRY, MEDICINAL

Marine Drugs Pub Date : 2024-09-05 DOI:10.3390/md22090407

Qi Tan, Xinyu Ye, Siqi Fu, Yihao Yin, Yufeng Liu, Jianying Wu, Fei Cao, Bo Wang, Tingshun Zhu, Wencong Yang, Zhigang She

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引用次数: 0

摘要

从红树林内生真菌 Xylaria arbuscula QYF 中分离出了 12 种化合物，包括 4 种未被描述的细胞分裂素、木犀草素 A-D (1-4)、4 种未被描述的多酮 (5-8) 和 4 种已知的细胞分裂素 (9-12)。通过广泛的光谱分析（一维和二维核磁共振、HRESIMS）、电子圆二色性（ECD）计算、13C NMR 计算和 DP4+ 分析、单晶 X 射线衍射以及改进的莫舍酯法，确定了它们的结构和绝对构型。化合物 1 和 2 是罕见的细胞分裂素氢过氧化物。在生物活性测定中，化合物 2 对金黄色葡萄球菌和白色念珠菌具有中等程度的抗菌活性，两者的 MIC 值均为 12.5 μM 化合物 10 对 MDA-MB-435 具有显著的细胞毒性活性，IC50 值为 3.61 ± 1.60 μM。

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The Cytochalasins and Polyketides from a Mangrove Endophytic Fungus Xylaria arbuscula QYF

Twelve compounds, including four undescribed cytochalasins, xylariachalasins A–D (1–4), four undescribed polyketides (5–8), and four known cytochalasins (9–12), were isolated from the mangrove endophytic fungus Xylaria arbuscula QYF. Their structures and absolute configurations were established by extensive spectroscopic analyses (1D and 2D NMR, HRESIMS), electronic circular dichroism (ECD) calculations, 13C NMR calculation and DP4+ analysis, single-crystal X-ray diffraction, and the modified Mosher ester method. Compounds 1 and 2 are rare cytochalasin hydroperoxides. In bioactivity assays, Compound 2 exhibited moderate antimicrobial activities against Staphylococcus aureus and Candida albicans with MIC values of 12.5 μM for both Compound 10 exhibited significant cytotoxic activity against MDA-MB-435 with an IC50 value of 3.61 ± 1.60 μM.

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.