Mohsen A. Sayed, Nahla. M. Ghazy, Asmaa A. H. El-Bassuony
{"title":"纳米粒子与精油组合的协同抗皮肤癣菌潜能","authors":"Mohsen A. Sayed, Nahla. M. Ghazy, Asmaa A. H. El-Bassuony","doi":"10.1007/s10904-024-03294-y","DOIUrl":null,"url":null,"abstract":"<p>Conventional antifungal therapies becoming less effective in treating dermatophytic infections. For this reason, researchers are looking for alternative treatments. The current research has tested the antifungal efficacy of eight novel synthesized metallic nanoparticle compounds: Ag<sub>0.49</sub>Cr<sub>2.51</sub>O<sub>4</sub>, Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub>, CoLa<sub>0.019</sub>Fe<sub>1.981</sub>O<sub>4</sub>, Co<sub>0.99</sub>Fe<sub>1.99</sub>O<sub>4</sub>, Ag<sub>0.99</sub>Cr<sub>1.01</sub>O<sub>2</sub>, Ca<sub>0.99</sub>Fe<sub>1.99</sub>O<sub>4</sub>, CoBi<sub>0.019</sub>Fe<sub>1.981</sub>O<sub>4</sub>, and Cu<sub>0.99</sub>Fe<sub>1.99</sub>O<sub>4</sub> were synthesized by a flash auto-combustion reaction to evaluate synergistic potential of the Np’s exhibited antifungal activity in combination with Cinnamon, clove, lemongrass, tea tree and thyme essential oils extracted by soxhlet method against <i>Microsporum canis</i>,<i> Trichophyton tonsurans</i>,<i> T. violaceum</i>,<i> T. verrucosum</i>,<i> and Epidermophyton floccosum</i>. Four nanoparticle compounds exhibited antifungal activity which were: Ag<sub>0.49</sub>Cr<sub>2.51</sub>O<sub>4</sub>, Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub>, CoLa<sub>0.019</sub>Fe<sub>1.981</sub>O<sub>4</sub>, and Co<sub>0.99</sub>Fe<sub>1.99</sub>O<sub>4</sub> against all tested dermatophytes. Maximum inhibition was recorded in the cases of Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub>, Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub> + cinnamon against <i>M.canis</i>. Least minimum inhibitory concentrations were attained by Cinnamon against <i>M. canis</i>, Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub> against <i>M.canis</i>,<i> T. tonsurans</i>, and <i>T.violaceum</i>, Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub>+Cinnamon against <i>M. canis</i>,<i> T. violaceum</i> and, <i>T. verrucosum</i>, Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub> + Clove, and Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub> + Lemongrass against <i>M. canis</i>. The study showed promising results regarding the synergistic antifungal efficacy of nanoparticle compounds combined with essential oils in the cases of Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub> with cinnamon, Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub> with clove and Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub> with lemon grass against all tested dermatophytes.</p>","PeriodicalId":639,"journal":{"name":"Journal of Inorganic and Organometallic Polymers and Materials","volume":"409 1","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synergistic Anti-Dermatophytic Potential of Nanoparticles and Essential Oils Combinations\",\"authors\":\"Mohsen A. Sayed, Nahla. M. Ghazy, Asmaa A. H. El-Bassuony\",\"doi\":\"10.1007/s10904-024-03294-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Conventional antifungal therapies becoming less effective in treating dermatophytic infections. For this reason, researchers are looking for alternative treatments. The current research has tested the antifungal efficacy of eight novel synthesized metallic nanoparticle compounds: Ag<sub>0.49</sub>Cr<sub>2.51</sub>O<sub>4</sub>, Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub>, CoLa<sub>0.019</sub>Fe<sub>1.981</sub>O<sub>4</sub>, Co<sub>0.99</sub>Fe<sub>1.99</sub>O<sub>4</sub>, Ag<sub>0.99</sub>Cr<sub>1.01</sub>O<sub>2</sub>, Ca<sub>0.99</sub>Fe<sub>1.99</sub>O<sub>4</sub>, CoBi<sub>0.019</sub>Fe<sub>1.981</sub>O<sub>4</sub>, and Cu<sub>0.99</sub>Fe<sub>1.99</sub>O<sub>4</sub> were synthesized by a flash auto-combustion reaction to evaluate synergistic potential of the Np’s exhibited antifungal activity in combination with Cinnamon, clove, lemongrass, tea tree and thyme essential oils extracted by soxhlet method against <i>Microsporum canis</i>,<i> Trichophyton tonsurans</i>,<i> T. violaceum</i>,<i> T. verrucosum</i>,<i> and Epidermophyton floccosum</i>. Four nanoparticle compounds exhibited antifungal activity which were: Ag<sub>0.49</sub>Cr<sub>2.51</sub>O<sub>4</sub>, Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub>, CoLa<sub>0.019</sub>Fe<sub>1.981</sub>O<sub>4</sub>, and Co<sub>0.99</sub>Fe<sub>1.99</sub>O<sub>4</sub> against all tested dermatophytes. Maximum inhibition was recorded in the cases of Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub>, Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub> + cinnamon against <i>M.canis</i>. Least minimum inhibitory concentrations were attained by Cinnamon against <i>M. canis</i>, Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub> against <i>M.canis</i>,<i> T. tonsurans</i>, and <i>T.violaceum</i>, Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub>+Cinnamon against <i>M. canis</i>,<i> T. violaceum</i> and, <i>T. verrucosum</i>, Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub> + Clove, and Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub> + Lemongrass against <i>M. canis</i>. The study showed promising results regarding the synergistic antifungal efficacy of nanoparticle compounds combined with essential oils in the cases of Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub> with cinnamon, Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub> with clove and Ag<sub>0.99</sub>Fe<sub>1.01</sub>O<sub>3</sub> with lemon grass against all tested dermatophytes.</p>\",\"PeriodicalId\":639,\"journal\":{\"name\":\"Journal of Inorganic and Organometallic Polymers and Materials\",\"volume\":\"409 1\",\"pages\":\"\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2024-08-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Inorganic and Organometallic Polymers and Materials\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1007/s10904-024-03294-y\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Inorganic and Organometallic Polymers and Materials","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s10904-024-03294-y","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
Synergistic Anti-Dermatophytic Potential of Nanoparticles and Essential Oils Combinations
Conventional antifungal therapies becoming less effective in treating dermatophytic infections. For this reason, researchers are looking for alternative treatments. The current research has tested the antifungal efficacy of eight novel synthesized metallic nanoparticle compounds: Ag0.49Cr2.51O4, Ag0.99Fe1.01O3, CoLa0.019Fe1.981O4, Co0.99Fe1.99O4, Ag0.99Cr1.01O2, Ca0.99Fe1.99O4, CoBi0.019Fe1.981O4, and Cu0.99Fe1.99O4 were synthesized by a flash auto-combustion reaction to evaluate synergistic potential of the Np’s exhibited antifungal activity in combination with Cinnamon, clove, lemongrass, tea tree and thyme essential oils extracted by soxhlet method against Microsporum canis, Trichophyton tonsurans, T. violaceum, T. verrucosum, and Epidermophyton floccosum. Four nanoparticle compounds exhibited antifungal activity which were: Ag0.49Cr2.51O4, Ag0.99Fe1.01O3, CoLa0.019Fe1.981O4, and Co0.99Fe1.99O4 against all tested dermatophytes. Maximum inhibition was recorded in the cases of Ag0.99Fe1.01O3, Ag0.99Fe1.01O3 + cinnamon against M.canis. Least minimum inhibitory concentrations were attained by Cinnamon against M. canis, Ag0.99Fe1.01O3 against M.canis, T. tonsurans, and T.violaceum, Ag0.99Fe1.01O3+Cinnamon against M. canis, T. violaceum and, T. verrucosum, Ag0.99Fe1.01O3 + Clove, and Ag0.99Fe1.01O3 + Lemongrass against M. canis. The study showed promising results regarding the synergistic antifungal efficacy of nanoparticle compounds combined with essential oils in the cases of Ag0.99Fe1.01O3 with cinnamon, Ag0.99Fe1.01O3 with clove and Ag0.99Fe1.01O3 with lemon grass against all tested dermatophytes.
期刊介绍：
Journal of Inorganic and Organometallic Polymers and Materials [JIOP or JIOPM] is a comprehensive resource for reports on the latest theoretical and experimental research. This bimonthly journal encompasses a broad range of synthetic and natural substances which contain main group, transition, and inner transition elements. The publication includes fully peer-reviewed original papers and shorter communications, as well as topical review papers that address the synthesis, characterization, evaluation, and phenomena of inorganic and organometallic polymers, materials, and supramolecular systems.
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