Bin Luo, Jiahui Lei, Rui Wen, Xiaoqin Hu, Shuyao Liu, Pingli Dong, Fang Lan, Yao Wu
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MXene/Metal–Organic Framework Heterojunctions Facilitate Bacterial-Infected Wound Repair via Exogenous and Endogenous Synergistic Stimulations
The antibiotic resistance of bacteria and the lack of efficient antibacterial agents result in significant worsening of microbial infection symptoms. To address this daunting issue, a multimodal antibacterial strategy that combines exogenous and endogenous stimulations is proposed. A novel two-dimensional heterojunction (termed MXP HJs) is developed by in situ growth of the metal–organic frameworks (MOFs) onto the MXene via the dielectric barrier discharge technique. Under light irradiation, MXP HJs exhibit excellent photocatalytic and photothermal performance to provide exogenous stimulation for killing bacteria. In addition, the MXP HJs promote electron transfer at the interfaces between the MXP HJs and bacteria, and this inhibits bacterial ribosomal pathways, resulting in endogenous antibacterial activity. Furthermore, MXP HJs can significantly promote wound healing through bacterial clearance, collagen deposition, and angiogenesis. Thus, this work lays the foundation for the development of a photocatalytic HJ platform that can be used in antibacterial applications for infectious wound repair.
期刊介绍:
ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.