美国饮用水中的消毒副产物与癌症死亡率。

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research Pub Date : 2024-09-10 DOI:10.1080/09603123.2024.2400701

Angelico Mendy

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引用次数: 0

摘要

三卤甲烷是主要的饮用水消毒副产物，可能致癌，美国规定三卤甲烷总含量 (TTHM) 上限为 80 µg/l。我们旨在确定美国各地饮用水中的总三卤甲烷和单个三卤甲烷是否与癌症死亡率的升高有关，我们对 1999 年至 2008 年期间参加全国健康与营养调查的 6260 名成年参与者进行了跟踪调查，以确定他们的死亡率，直至 2019 年（中位数：14.4 年）。基线时，饮用水中 TTHM 的几何平均数（标准误差）为 9.61 (0.85) µg/l。在随访期间，共有 873 人死亡，其中 207 人死于癌症。在对相关协变量进行调整的 Cox 比例危险回归中，饮用水中的三卤甲烷（HR：1.45，95% CI：1.16-1.82）、氯仿（HR：1.35，95% CI：1.12-1.64）和溴二氯甲烷（HR：1.30，95% CI：1.05-1.59）与癌症死亡率增加 30% 至 45% 相关。因此，饮用水中的三卤甲烷，尤其是氯仿和溴二氯甲烷，可能是导致癌症死亡的风险因素。

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Disinfection byproducts in US drinking water and cancer mortality.

Trihalomethanes, the main drinking water disinfection byproducts, may be carcinogenic and are regulated to amaximum total trihalomethanes (TTHM) of 80 µg/l in the US. We aimed to determine whether total and individual trihalomethanes in drinking water across the US are associated with higher cancer mortality in 6,260 adult participants to the National Health and Nutrition Examination Surveys from 1999 to 2008 followed for mortality until 2019 (median: 14.4 years). At baseline, the geometric mean (standard error) of TTHM in drinking water was 9.61 (0.85) µg/l. During follow-up, 873 deaths occurred, including 207 from cancer. In Cox proportional hazards regression adjusted for relevant covariates, drinking water TTHM (HR: 1.45, 95% CI: 1.16-1.82), chloroform (HR: 1.35, 95% CI: 1.12-1.64), and bromodichloromethane (HR: 1.30, 95% CI: 1.05-1.59) were associated with 30% to 45% higher cancer mortality. Therefore, drinking water trihalomethanes, especially chloroform and bromodichloromethane maybe risk factors for cancer mortality.

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来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.