家庭成员对 AUD 爱侣的奖励性激活反应

IF 1 Q3 PSYCHOLOGY, CLINICAL
Sterling T. Shumway, Spencer D. Bradshaw, Mazie Zielinski, Thomas G. Kimball, Jacob T. Fisher
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引用次数: 0

摘要

患有酒精使用障碍(AUD)的亲人的家庭成员会承受很大的压力和其他不利影响,尤其是那些一线照顾者,因此他们最接近酒精使用障碍患者。先前的研究表明,这些家庭成员的前额叶皮层对其亲人图像的反应会发生改变,而这些反应与酒精中毒症患者大脑对酒精线索的反应有相似之处。目前的研究旨在通过检测家庭成员大脑的全脑功能激活来扩展这项研究。研究人员使用功能磁共振成像(fMRI)测量了 10 名有确诊 AUD 患者的家庭成员以及 10 名对照组参与者在事件相关研究范式中的激活反应。广义线性建模(GLM)的结果表明,患有 AUD 的家庭成员的左侧海马区和左侧杏仁核有明显的激活反应,而且这种激活反应明显高于对照组。这两个皮层下区域在奖赏网络中发挥作用,本研究发现它们的激活可能与基于奖赏的 "接近 "反应有关--这进一步将受影响家庭成员的大脑功能与 AUD 患者的大脑功能相提并论。这种认识会影响临床医生如何为 AUD 患者的家庭成员提供服务。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Family Members’ Reward-Based Activation in Response to an AUD Love-One

Family Members’ Reward-Based Activation in Response to an AUD Love-One

Family members of a loved-one with an alcohol use disorder (AUD) experience much stress and other adverse impacts, especially those that are frontline caregivers and therefore most proximal to AUD. Previous research has shown such family members experience altered functioning of the prefrontal cortex in response to images of their loved-one, and these responses have similarities to brain responses to alcohol cues for a person with AUD. The current study aimed to expand this research by examining whole-brain functional activation of family members’ brains. Functional magnetic resonance imaging (fMRI) was used to measure activation responses of 10 family members with a loved-one with diagnosed AUD, as well as that of 10 control group participants, during an event-related research paradigm. Results from Generalized Linear Modeling (GLM) indicated significant activation in the left hippocampus and left amygdala for family members of an AUD loved-one, and this activation was significantly greater than that of a control group. These two subcortical regions play a role in the reward network and their activation found in this study may be associated with a reward-based “approach” response – drawing further parallels between the functioning of the impacted family member’s brain and that of the brain of someone with AUD. This understanding influences how clinicians might provide services to family members of those with AUD.

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来源期刊
CONTEMPORARY FAMILY THERAPY
CONTEMPORARY FAMILY THERAPY PSYCHOLOGY, CLINICAL-
CiteScore
2.50
自引率
7.70%
发文量
34
期刊介绍: Contemporary Family Therapy: An International Journal (COFT) is is a quarterly, peer-reviewed publication that presents the latest developments in research, practice, theory, and training in couple and family therapy. COFT publishes applied and basic research with implications for systemic theory, treatment, and policy. COFT appreciates a multidisciplinary approach, and welcomes manuscripts which address processes and outcomes in systemic treatment across modalities and within broader social contexts. The journal’s content is relevant to systemic therapy practitioners and researchers, as well as marriage and family therapists, family psychologists, clinical social workers, and social policy specialists.
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