突触对伽马节律间歇同步的影响

IF 3.1 3区 工程技术 Q2 NEUROSCIENCES
Quynh-Anh Nguyen, Leonid L. Rubchinsky
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引用次数: 0

摘要

伽马频段的神经活动同步与各种认知现象有关。伽马同步异常可能是精神分裂症和自闭症谱系障碍等多种神经和精神疾病的症状根源。伽马频段的神经振荡特性关键取决于底层回路的突触特性。本研究探讨了锥体-神经元间回路的突触特性如何不仅影响平均同步强度,而且影响神经同步的精细时间模式。如果两个信号仅表现出适度的同步强度,那么就有可能将这些动态视为同步和非同步状态之间的交替。我们使用一个产生锥体-神经元间伽玛振荡的连接电路模型来探索同步和非同步间隔的时间模式。突触强度的变化可能会改变同步动态的时间模式(即使平均同步强度没有变化)。局部突触连接的数值越大,非同步化持续时间越长,而长程突触连接的数值越大,非同步化持续时间越短。此外,我们还发现,具有不同时间同步模式的电路可能对突触输入具有不同的敏感性。因此,突触强度的改变可能不仅通过改变伽马振荡的平均同步水平,还通过改变极短时间尺度上的同步模式来介导神经回路的生理特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Synaptic effects on the intermittent synchronization of gamma rhythms

Synaptic effects on the intermittent synchronization of gamma rhythms

Synchronization of neural activity in the gamma frequency band is associated with various cognitive phenomena. Abnormalities of gamma synchronization may underlie symptoms of several neurological and psychiatric disorders such as schizophrenia and autism spectrum disorder. Properties of neural oscillations in the gamma band depend critically on the synaptic properties of the underlying circuits. This study explores how synaptic properties in pyramidal-interneuronal circuits affect not only the average synchronization strength but also the fine temporal patterning of neural synchrony. If two signals show only moderate synchrony strength, it may be possible to consider these dynamics as alternating between synchronized and desynchronized states. We use a model of connected circuits that produces pyramidal-interneuronal gamma oscillations to explore the temporal patterning of synchronized and desynchronized intervals. Changes in synaptic strength may alter the temporal patterning of synchronized dynamics (even if the average synchrony strength is not changed). Larger values of local synaptic connections promote longer desynchronization durations, while larger values of long-range synaptic connections promote shorter desynchronization durations. Furthermore, we show that circuits with different temporal patterning of synchronization may have different sensitivity to synaptic input. Thus, the alterations of synaptic strength may mediate physiological properties of neural circuits not only through change in the average synchrony level of gamma oscillations, but also through change in how synchrony is patterned in time over very short time scales.

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来源期刊
Cognitive Neurodynamics
Cognitive Neurodynamics 医学-神经科学
CiteScore
6.90
自引率
18.90%
发文量
140
审稿时长
12 months
期刊介绍: Cognitive Neurodynamics provides a unique forum of communication and cooperation for scientists and engineers working in the field of cognitive neurodynamics, intelligent science and applications, bridging the gap between theory and application, without any preference for pure theoretical, experimental or computational models. The emphasis is to publish original models of cognitive neurodynamics, novel computational theories and experimental results. In particular, intelligent science inspired by cognitive neuroscience and neurodynamics is also very welcome. The scope of Cognitive Neurodynamics covers cognitive neuroscience, neural computation based on dynamics, computer science, intelligent science as well as their interdisciplinary applications in the natural and engineering sciences. Papers that are appropriate for non-specialist readers are encouraged. 1. There is no page limit for manuscripts submitted to Cognitive Neurodynamics. Research papers should clearly represent an important advance of especially broad interest to researchers and technologists in neuroscience, biophysics, BCI, neural computer and intelligent robotics. 2. Cognitive Neurodynamics also welcomes brief communications: short papers reporting results that are of genuinely broad interest but that for one reason and another do not make a sufficiently complete story to justify a full article publication. Brief Communications should consist of approximately four manuscript pages. 3. Cognitive Neurodynamics publishes review articles in which a specific field is reviewed through an exhaustive literature survey. There are no restrictions on the number of pages. Review articles are usually invited, but submitted reviews will also be considered.
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