超越模块化增强子:顺式调控进化中的新问题

IF 16.7 1区 生物学 Q1 ECOLOGY
Jeanne M.C. McDonald, Robert D. Reed
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引用次数: 0

摘要

我们对顺式调控元件工作原理的理解进展迅速,超过了我们的进化模型。在这篇综述中,我们将探讨新的机理发现对进化发育生物学的影响。我们将重点讨论三个不同的问题:进化创新是更多地通过修改旧的顺式调控元件还是出现新的顺式调控元件来实现;单个元件在多大程度上是特异和自主的,还是多功能和相互依存的;顺式调控结构的稳健性如何影响性状进化的速度。这些讨论使我们对顺式调控的进化演变提出了新的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Beyond modular enhancers: new questions in cis-regulatory evolution

Our understanding of how cis-regulatory elements work has advanced rapidly, outpacing our evolutionary models. In this review, we consider the implications of new mechanistic findings for evolutionary developmental biology. We focus on three different debates: whether evolutionary innovation occurs more often via the modification of old cis-regulatory elements or the emergence of new ones; the extent to which individual elements are specific and autonomous or multifunctional and interdependent; and how the robustness of cis-regulatory architectures influences the rate of trait evolution. These discussions lead us to propose new questions for the evo-devo of cis-regulation.

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来源期刊
Trends in ecology & evolution
Trends in ecology & evolution 生物-进化生物学
CiteScore
26.50
自引率
3.00%
发文量
178
审稿时长
6-12 weeks
期刊介绍: Trends in Ecology & Evolution (TREE) is a comprehensive journal featuring polished, concise, and readable reviews, opinions, and letters in all areas of ecology and evolutionary science. Catering to researchers, lecturers, teachers, field workers, and students, it serves as a valuable source of information. The journal keeps scientists informed about new developments and ideas across the spectrum of ecology and evolutionary biology, spanning from pure to applied and molecular to global perspectives. In the face of global environmental change, Trends in Ecology & Evolution plays a crucial role in covering all significant issues concerning organisms and their environments, making it a major forum for life scientists.
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