胶质瘤中的葡萄糖代谢:ncRNA 的新发现

IF 5.3 2区 医学 Q1 ONCOLOGY
Jun Rong, Qifu Wang, Tingzheng Li, Jin Qian, Jinchao Cheng
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引用次数: 0

摘要

胶质瘤是一种原发性脑肿瘤,生长迅速,预后不良,并可在脑内扩散。胶质瘤细胞依赖葡萄糖作为主要能量来源,糖酵解在肿瘤发生和发展过程中起着至关重要的作用。在胶质瘤的整个发展过程中,底物利用会发生变化,以促进能量生成和生物量积累。这种代谢重编程会促进胶质瘤细胞的增殖和转移,并最终降低传统疗法的疗效。非编码 RNA(ncRNA)参与了肿瘤发生和发展过程中的几种葡萄糖代谢途径。这些 RNA 通过调节糖酵解途径关键基因的表达来影响细胞活力和葡萄糖代谢。它们可以通过影响癌基因和抑制基因的转录和转录后调控,直接或间接影响胶质瘤细胞的糖酵解。在这篇综述中,我们讨论了 ncRNA 在胶质瘤细胞和肿瘤微环境代谢重编程中的作用,以及它们在胶质瘤糖代谢通路中的异常表达。此外,我们还整合了现有的理论知识,以便将这类新兴的生物标志物用作胶质瘤的生物学指标和潜在治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Glucose metabolism in glioma: an emerging sight with ncRNAs
Glioma is a primary brain tumor that grows quickly, has an unfavorable prognosis, and can spread intracerebrally. Glioma cells rely on glucose as the major energy source, and glycolysis plays a critical role in tumorigenesis and progression. Substrate utilization shifts throughout glioma progression to facilitate energy generation and biomass accumulation. This metabolic reprogramming promotes glioma cell proliferation and metastasis and ultimately decreases the efficacy of conventional treatments. Non-coding RNAs (ncRNAs) are involved in several glucose metabolism pathways during tumor initiation and progression. These RNAs influence cell viability and glucose metabolism by modulating the expression of key genes of the glycolytic pathway. They can directly or indirectly affect glycolysis in glioma cells by influencing the transcription and post-transcriptional regulation of oncogenes and suppressor genes. In this review, we discussed the role of ncRNAs in the metabolic reprogramming of glioma cells and tumor microenvironments and their abnormal expression in the glucometabolic pathway in glioma. In addition, we consolidated the existing theoretical knowledge to facilitate the use of this emerging class of biomarkers as biological indicators and potential therapeutic targets for glioma.
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来源期刊
CiteScore
10.90
自引率
1.70%
发文量
360
审稿时长
1 months
期刊介绍: Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.
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