2012-2017 年南非诊断实验室采集的人类标本中葡萄球菌的抗菌药耐药性

IF 4.1 2区生物学 Q2 MICROBIOLOGY

Microorganisms Pub Date : 2024-09-09 DOI:10.3390/microorganisms12091862

Themba Titus Sigudu, James Wabwire Oguttu, Daniel Nenene Qekwana

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引用次数: 0

摘要

抗菌药耐药性（AMR）是一项重大的世界性健康挑战，它与病程延长、医疗成本增加和高死亡率有关。本研究考察了 2012 年至 2017 年间从南非诊断实验室获得的人类葡萄球菌分离物中的 AMR 模式和预测因素。本研究检查了来自 404 217 株分离物的数据，评估了不同特征（如年龄、样本来源、葡萄球菌种类和研究时期）的耐药率。对氯唑西林的耐药性最高（70.3%），而对可乐定的耐药性最低（0.1%）。在研究期间，AMR 呈明显下降趋势（p < 0.05），而在同一时期，耐多药（MDR）呈明显上升趋势（p < 0.05）。标本类型、生物种类和分离年份与 AMR 结果之间存在明显关联（p < 0.05）。标本类型和季节与 MDR 之间也存在明显的关联（p < 0.05）。所观察到的 AMR 高水平和 MDR 不断增长的趋势令人担忧公共卫生问题。临床医生在决定治疗方案时应考虑到这些发现。应继续监测葡萄球菌中的 AMR，并在人类医疗中合理使用抗菌药物。

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Antimicrobial Resistance of Staphylococcus spp. from Human Specimens Submitted to Diagnostic Laboratories in South Africa, 2012–2017

Antimicrobial resistance (AMR) poses a significant worldwide health challenge associated with prolonged illnesses, increased healthcare costs, and high mortality rates. The present study examined the patterns and predictors of AMR among human Staphylococcus isolates obtained from diagnostic laboratories in South Africa between 2012 and 2017. This study examined data from 404 217 isolates, assessing resistance rates across different characteristics such as age, sample origin, Staphylococcus species, and study period. The highest resistance was observed against cloxacillin (70.3%), while the lowest resistance was against Colistin (0.1%). A significant (p < 0.05) decreasing trend in AMR was observed over the study period, while a significant increasing temporal trend (p < 0.05) was observed for multidrug resistance (MDR) over the same period. A significant (p < 0.05) association was observed between specimen type, species of organism, and year of isolation with AMR outcome. Significant (p < 0.05) associations were observed between specimen type and season with MDR. The observed high levels of AMR and a growing trend in MDR are concerning for public health. Clinicians should take these findings into account when deciding on therapeutic options. Continued monitoring of AMR among Staphylococcus spp. and judicious use of antimicrobials in human medicine should be promoted.

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来源期刊

Microorganisms Medicine-Microbiology (medical)

CiteScore

7.40

自引率

6.70%

发文量

2168

审稿时长

20.03 days

期刊介绍： Microorganisms (ISSN 2076-2607) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to prokaryotic and eukaryotic microorganisms, viruses and prions. It publishes reviews, research papers and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.