质子和碳离子微束疗法:从建模到治疗

IF 0.6 4区 物理与天体物理 Q4 PHYSICS, PARTICLES & FIELDS
I. A. Pshenichnov, U. A. Dmitrieva, S. D. Savenkov, A. O. Svetlichnyi
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引用次数: 0

摘要

摘要 利用 Geant4 工具包对组织样介质中的质子和 12C 微型光束阵列进行了建模。模拟中使用了一组光束能量,为质子和 12C 提供了一个延伸 6 厘米深度的 Spead-out Bragg 峰 (SOBP)。在这两种情况下,0.3 或 0.5 mm FWHM 的射束都被安排在矩形或六边形网格的水模型入口处,以比较两种射弹和不同的微型光束模式。计算并比较了质子和 12C 的差分和累积剂量体积直方图(DVH)作为剂量均匀性指标。由于质子射弹的横向散射比 12C 射弹强,因此质子射弹很容易实现剂量均匀分布。为 0.3 毫米或 0.5 毫米微型光束计算出的累积 DVH 在靶体积内几乎重合,但在不同的网格模式下会出现分歧。与此相反,两种网格模式下的累积进入 DVH 值相似,但 0.3 毫米和 0.5 毫米微光束的累积进入 DVH 值不同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Proton and Carbon-Ion Minibeam Therapy: From Modeling to Treatment

Proton and Carbon-Ion Minibeam Therapy: From Modeling to Treatment

Proton and Carbon-Ion Minibeam Therapy: From Modeling to Treatment

Arrays of minibeams of protons and 12C in tissue-like media were modeled with Geant4 toolkit. A set of beam energies was used in simulations to provide a Spead-out Bragg peak (SOBP) extended by 6 cm in depth for protons as well as for 12C. In both cases, beams of 0.3 or 0.5 mm FWHM were arranged at the entrance to a water phantom either on a rectangular or an hexagonal grid to compare two kinds of projectiles and different minibeam patterns. Differential and cumulative dose-volume histograms (DVH) were calculated and compared for protons and 12C as dose uniformity metrics. A uniform dose distribution was easily achieved with protons due to an enhanced lateral scattering of these projectiles in comparison to 12C. The cumulative DVHs calculated for 0.3 or 0.5 mm minibeams almost coincide in the target volume, but diverge for different grid patterns. In contrast, cumulative entry DVHs were found similar for both grid patterns, but different for 0.3 and 0.5 mm minibeams.

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来源期刊
Physics of Particles and Nuclei
Physics of Particles and Nuclei 物理-物理:粒子与场物理
CiteScore
1.00
自引率
0.00%
发文量
116
审稿时长
6-12 weeks
期刊介绍: The journal Fizika Elementarnykh Chastits i Atomnogo Yadr of the Joint Institute for Nuclear Research (JINR, Dubna) was founded by Academician N.N. Bogolyubov in August 1969. The Editors-in-chief of the journal were Academician N.N. Bogolyubov (1970–1992) and Academician A.M. Baldin (1992–2001). Its English translation, Physics of Particles and Nuclei, appears simultaneously with the original Russian-language edition. Published by leading physicists from the JINR member states, as well as by scientists from other countries, review articles in this journal examine problems of elementary particle physics, nuclear physics, condensed matter physics, experimental data processing, accelerators and related instrumentation ecology and radiology.
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