Miłosława Zowczak-Drabarczyk, Jacek Białecki, Teresa Grzelak, Mikołaj Michalik, Dorota Formanowicz
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引用次数: 0
摘要
众所周知,硒(Se)、锌(Zn)和铜(Cu)与致癌有关,并参与防御活性氧(ROS)。本研究旨在评估血清中硒、锌和铜的浓度以及血浆总抗氧化状态(TAS)在低硒和低锌人群中诊断结直肠癌(CRC)和结直肠腺瘤(CRA)的临床实用性。根据临床检查和结肠镜/组织病理学检查,患者(n = 79)被分为三组:结直肠癌(n = 30)、结直肠腺瘤(n = 19)和对照组(CONTROL,n = 30)。CRC 组的血清 Se 浓度比 CRA 组(低 9.1%,P < 0.0001)和 CONTROL 组(低 7.9%,P < 0.0001)低。与对照组相比,CRA 组的血清锌浓度降低了 17.9%,p = 0.019。与对照组相比,CRC 组的血浆 TAS 降低了 27.8%,p = 0.017。与对照组相比,CRA 组的血清锌浓度也有所下降。CRC 组的血浆 TAS 低于对照组。ROC(接收器操作特征)曲线分析表明,Se水平在区分CRC组与CRA组(ROC曲线下面积(AUC)为0.958,灵敏度为84.21%,特异度为100%)和CONTROL组(AUC为0.873,灵敏度为100%,特异度为66.67%)方面的诊断效用最高。Zn 和 TAS 水平在区分不同组别方面具有显著的准确性。在人群中,Se、Zn 和 TAS 检测可用于个体化的结直肠腺瘤和癌症风险分析。
Selenium, Zinc, and Plasma Total Antioxidant Status and the Risk of Colorectal Adenoma and Cancer
Selenium (Se), zinc (Zn), and copper (Cu) are known to be involved in carcinogenesis and participate in the defence against reactive oxygen species (ROS). This study aimed to evaluate the clinical utility of serum Se, Zn, and Cu concentrations and plasma total antioxidant status (TAS) in the diagnosis of colorectal cancer (CRC) and colorectal adenoma (CRA) in a population of low Se and borderline Zn status. Based on clinical examination and colonoscopy/histopathology, the patients (n = 79) were divided into three groups: colorectal cancer (n = 30), colorectal adenoma (n = 19), and controls (CONTROL, n = 30). The serum Se concentration was lower in the CRC group than in the CRA group (by 9.1%, p < 0.0001) and the CONTROL group (by 7.9%, p < 0.0001). In turn, the serum Zn concentration was decreased in the CRA group (by 17.9%, p = 0.019) when compared to the CONTROL group. Plasma TAS was lower in the CRC group (by 27.8%, p = 0.017) than in the CONTROL group. In turn, the serum Zn concentration was decreased in the CRA group when compared to the CONTROL group. Plasma TAS was lower in the CRC group than in the CONTROL group. ROC (receiver operating characteristic) curve analysis revealed that the Se level was of the highest diagnostic utility for the discrimination of the CRC group from both the CRA group (area under ROC curve (AUC) 0.958, sensitivity 84.21%, specificity 100%) and the CONTROL group (AUC 0.873, sensitivity 100%, specificity 66.67%). The Zn and TAS levels were significantly accurate in the differentiation between the groups. An individualised risk of colorectal adenoma and cancer approach could comprise Se, Zn, and TAS assays in the population.
MetabolitesBiochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
5.70
自引率
7.30%
发文量
1070
审稿时长
17.17 days
期刊介绍:
Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.