椭圆形颗粒导致的纳米孔离子流阻塞

IF 2.4 3区 物理与天体物理 Q1 Mathematics
Dmitriy V. Melnikov, Nelson R. Barker, Maria E. Gracheva
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引用次数: 0

摘要

固态膜中的纳米孔已被用于检测、识别、过滤和表征纳米粒子和生物分子。在这项研究中,我们模拟了椭圆形纳米粒子通过纳米孔时的离子流动。我们通过数值求解泊松-奈恩斯特-普朗克方程,得到了不同长径比、大小和方向的转运粒子的离子电流值。通过将纳米孔道中离子电流的现有理论模型扩展到椭圆形粒子,我们提出了半经验拟合公式,该公式对计算数据的描述精度在 5%以内。我们还演示了如何利用推导出的公式从现有的实验数据中确定纳米粒子的尺寸,这可能会在仿生技术中得到有用的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Ionic current blockade in a nanopore due to an ellipsoidal particle

Ionic current blockade in a nanopore due to an ellipsoidal particle
Nanopores in solid-state membranes have been used to detect, identify, filter, and characterize nanoparticles and biological molecules. In this work, we simulate an ionic flow through a nanopore while an ellipsoidal nanoparticle translocates through a pore. We numerically solve the Poisson-Nernst-Planck equations to obtain the ionic current values for different aspect ratios, sizes, and orientations of a translocating particle. By extending the existing theoretical model for the ionic current in the nanopore to the particles of ellipsoidal shape, we propose semiempirical fitting formulas which describe our computed data within 5% accuracy. We also demonstrate how the derived formulas can be used to identify the dimensions of nanoparticles from the available experimental data which may have useful applications in bionanotechnology.
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来源期刊
Physical review. E
Physical review. E 物理-物理:流体与等离子体
CiteScore
4.60
自引率
16.70%
发文量
0
审稿时长
3.3 months
期刊介绍: Physical Review E (PRE), broad and interdisciplinary in scope, focuses on collective phenomena of many-body systems, with statistical physics and nonlinear dynamics as the central themes of the journal. Physical Review E publishes recent developments in biological and soft matter physics including granular materials, colloids, complex fluids, liquid crystals, and polymers. The journal covers fluid dynamics and plasma physics and includes sections on computational and interdisciplinary physics, for example, complex networks.
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