改善姜黄素特性的玉米蛋白-甲基纤维素二元纳米共轭：可溶性、控释性和抗癌活性

IF 2.9 4区化学 Q2 POLYMER SCIENCE

Polymer International Pub Date : 2024-08-28 DOI:10.1002/pi.6694

Sana F Abaza, Nihal S Elbialy, Noha Mohamed

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引用次数: 0

摘要

为治疗癌症，利用天然化合物开发了一种新型纳米载体。将玉米蛋白（Z）和甲基纤维素（MC）多糖配制成营养保健品姜黄素（Cur）的纳米载体。在透射电子显微镜图像中，玉米蛋白-甲基纤维素纳米共轭物（ZMC）呈球形/单分散状态。ZMC 和 ZMC@Cur 的水动力学尺寸分别为 164 ± 20.2 nm 和 190 ± 28.2 nm。对这两种配方进行了 zeta 电位、差示扫描量热仪、傅立叶变换红外光谱和 X 射线衍射分析。姜黄素的封装效率为 92%，其释放曲线对 pH 值有响应。利用 MTT 法，ZMC@Cur 对 MCF-7 和 HepG2 有显著的细胞毒性作用，其效果超过姜黄素。这凸显了 ZMC@Cur 在增强姜黄素特性从而促进癌细胞死亡方面的关键作用。与游离姜黄素相比，ZMC@Cur 能显著促进癌细胞的 DNA 损伤，这是由于姜黄素能精确地靶向进入细胞核。因此，所提出的仿生复合材料是姜黄素的有效载体，通过改善姜黄素的药用特性，在抗癌方面发挥了重要作用。© 2024 化学工业协会。

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Binary nanoconjugation of zein–methylcellulose for improving curcumin properties: solubility, controlled release and anticancer activity

For cancer treatment, a novel nanocarrier has been developed, utilizing natural compounds. Zein protein (Z) and methylcellulose (MC) polysaccharide were formulated as a nanocarrier for nutraceutical curcumin (Cur). The zein–methylcellulose nanoconjugate (ZMC) appeared spherical/monodispersed in transmission electron microscopy images. Hydrodynamic sizes were 164 ± 20.2 and 190 ± 28.2 nm for ZMC and ZMC@Cur, respectively. For both formulations, zeta potential, differential scanning calorimetry, Fourier transform infrared spectroscopy and X‐ray diffraction analyses were conducted. Curcumin encapsulation efficiency was 92%, and its release profile was pH responsive. Using MTT assay, ZMC@Cur demonstrated a significant cytotoxic effect against MCF‐7 and HepG2, surpassing the impact of curcumin. This underscores the pivotal role of ZMC@Cur in enhancing curcumin properties, thereby potentiating cancer cell death. Compared with free curcumin, ZMC@Cur markedly promoted DNA damage in cancer cells, owing to precise curcumin targeting into the nucleus. Accordingly, the proposed bionanocomposite stands as an efficient vehicle for curcumin, showcasing its crucial role in combating cancer via improving the pharmaceutical properties of curcumin. © 2024 Society of Chemical Industry.

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来源期刊

Polymer International 化学-高分子科学

CiteScore

7.10

自引率

3.10%

发文量

135

审稿时长

4.3 months

期刊介绍： Polymer International (PI) publishes the most significant advances in macromolecular science and technology. PI especially welcomes research papers that address applications that fall within the broad headings Energy and Electronics, Biomedical Studies, and Water, Environment and Sustainability. The Journal’s editors have identified these as the major challenges facing polymer scientists worldwide. The Journal also publishes invited Review, Mini-review and Perspective papers that address these challenges and others that may be of growing or future relevance to polymer scientists and engineers.