利用超薄晶体中的上转换技术实现长波长、高分辨率显微技术

IF 5.4 1区 物理与天体物理 Q1 OPTICS
APL Photonics Pub Date : 2024-09-03 DOI:10.1063/5.0217145
P. Tidemand-Lichtenberg, C. Pedersen
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引用次数: 0

摘要

本文研究了一种基于超薄非线性晶体频率上转换的新方法,该方法可用于 5-12 µm 范围内的高分辨率红外(IR)显微镜,这是生物医学研究的一个重要领域。传统的红外成像会受到衍射造成的空间分辨率限制,而使用超薄晶体进行上转换成像则可以解决这一问题。本研究结合了可调谐红外量子级联激光器和短波长混合激光器,以规避由瑞利准则决定的经典分辨率限制。微米级分辨率小信号上转换成像的详细数值模型与实验数据显示出良好的一致性。所提出的方法为无标记生物医学诊断和光谱成像的红外应用开辟了新途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long-wavelength, high-resolution microscopy using upconversion in ultra-thin crystals
In this paper, a novel approach based on frequency upconversion in ultra-thin nonlinear crystals is investigated for use in high-resolution infrared (IR) microscopy in the 5–12 µm range, an important domain for biomedical research. Traditional IR imaging encounters spatial resolution constraints due to diffraction, which are addressed via upconversion imaging using ultra-thin crystals. The present work combines a tunable IR quantum cascade laser and a short wavelength mixing laser to circumvent the classical resolution limit dictated by the Rayleigh criterion. A detailed numerical model for small signal upconversion imaging at μm-scale resolution shows good agreement with experimental data. The presented approach opens new avenues for IR applications for label-free biomedical diagnostics and spectral imaging.
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来源期刊
APL Photonics
APL Photonics Physics and Astronomy-Atomic and Molecular Physics, and Optics
CiteScore
10.30
自引率
3.60%
发文量
107
审稿时长
19 weeks
期刊介绍: APL Photonics is the new dedicated home for open access multidisciplinary research from and for the photonics community. The journal publishes fundamental and applied results that significantly advance the knowledge in photonics across physics, chemistry, biology and materials science.
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