脑室下区的结构、功能及对神经疾病的影响

IF 6.9 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Genes & Diseases Pub Date : 2024-08-26 DOI:10.1016/j.gendis.2024.101398

Kaishu Li, Yin Zheng, Shubing Cai, Zhiming Fan, Junyi Yang, Yuanrun Liu, Shengqi Liang, Meihui Song, Siyuan Du, Ling Qi

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引用次数: 0

摘要

脑室下区（SVZ）是侧脑室周围的一个区域，其中含有神经干细胞和神经祖细胞，它们可以增殖和分化成各种神经细胞和神经胶质细胞。SVZ细胞在神经变性、神经损伤和多形性胶质母细胞瘤等神经系统疾病中发挥着重要作用。研究SVZ的解剖、结构、组成、生理、疾病关联和相关机制对神经干细胞治疗和治疗/预防神经系统疾病意义重大。然而，SVZ细胞增殖、分化和迁移的调控机制、向受损区域输送细胞以及免疫反应方面仍存在挑战。对SVZ功能的深入研究和相关治疗方法的开发，可为治疗脑损伤和退行性疾病提供新的见解和方法，并为神经干细胞疗法提供科学依据。本综述总结了有关SVZ和神经系统疾病的研究成果，为相关疗法提供参考。

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The subventricular zone structure, function and implications for neurological disease

The subventricular zone (SVZ) is a region surrounding the lateral ventricles that contains neural stem cells and neural progenitor cells, which can proliferate and differentiate into various neural and glial cells. SVZ cells play important roles in neurological diseases like neurodegeneration, neural injury, and glioblastoma multiforme. Investigating the anatomy, structure, composition, physiology, disease associations, and related mechanisms of SVZ is significant for neural stem cell therapy and treatment/prevention of neurological disorders. However, challenges remain regarding the mechanisms regulating SVZ cell proliferation, differentiation, and migration, delivering cells to damaged areas, and immune responses. In-depth studies of SVZ functions and related therapeutic developments may provide new insights and approaches for treating brain injuries and degenerative diseases, as well as a scientific basis for neural stem cell therapy. This review summarizes research findings on SVZ and neurological diseases to provide references for relevant therapies.

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来源期刊

Genes & Diseases Multiple-

CiteScore

7.30

自引率

0.00%

发文量

347

审稿时长

49 days

期刊介绍： Genes & Diseases is an international journal for molecular and translational medicine. The journal primarily focuses on publishing investigations on the molecular bases and experimental therapeutics of human diseases. Publication formats include full length research article, review article, short communication, correspondence, perspectives, commentary, views on news, and research watch. Aims and Scopes Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis will be placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.