用于银屑病协同治疗的带结构色标的纳米酶微球

IF 5.3 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
APL Materials Pub Date : 2024-09-03 DOI:10.1063/5.0229803
Nengjie Yang, Yuting Huang, Chen Dong, Chi Sun, Peipei Xi, Yuexiao Dai, Rui Zhao, Yunan Wang, Yujuan Zhu, Zhifeng Gu
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引用次数: 0

摘要

银屑病是一种由免疫系统介导的皮肤病,以出现红斑为主要症状。银屑病是一种反复发作的慢性炎症性疾病,受遗传和环境因素的影响,目前尚无有效的治疗方法。考虑到银屑病的多方面病因,协同疗法比单一疗法具有更大的优势,这已成为治疗各种疾病的常用方法。在此,我们介绍了用于银屑病协同治疗的带有结构色标的纳米酶微球。其中,微球水凝胶是由可食用的羟丙基纤维素(HPC)制成的,它能在溶液的变性条件下生成光子液晶介相。通过调整水凝胶成分,微球可具有不同的功能,包括保湿(石蜡)、cfDNA 清除(壳聚糖)和抗炎(氧化铈纳米酶)。为了方便患者使用,我们利用 HPC 的溶解特性,定制了具有不同特性的水凝胶滴剂,并赋予其不同的鲜艳结构色彩。特别值得一提的是,体外和体内实验都证明了编码结构色微球的显著治疗效果。绿色保湿微球有助于缓解皮肤干燥、脱皮;蓝色 cfDNA 清除微球和红色消炎微球可显著减轻皮肤炎症。更重要的是,编码微球的组合疗法发挥了协同效应,包括增加体重、增厚表皮层和减少免疫激活。总之,这种协同治疗为个性化治疗银屑病和各种炎症性皮肤病提供了一个前景广阔的平台。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nanozyme microspheres with structural color-coding labels for synergistic therapy of psoriasis
Psoriasis is an immune system-mediated skin disease identified by the appearance of erythematous as a central symptom. As a recurrent and chronic inflammatory disease, psoriasis is influenced by both genetic and environmental factors and is known to be with no effective cure. Considering a multifaceted etiology of psoriasis, synergistic therapy exhibits great benefits over monotherapy, which becomes common for the treatment of various diseases. Herein, we present the nanozyme microspheres with structural color-coding labels for synergistic therapy of psoriasis. In particular, microsphere hydrogel is fabricated by the edible hydroxypropyl cellulose (HPC), which can generate a photonic liquid crystalline mesophase under lyotropic conditions in solution. Through adjustment of hydrogel components, microspheres endow with different functions, including moisturizing (paraffin), cfDNA scavenging (chitosan), and anti-inflammation (cerium oxide nanozyme). To improve patient convenience, hydrogel drops with different properties are tailored with different vivid structural colors by exploiting the lyotropic behavior of HPC. Of particular note, both in vitro and in vivo experiments have demonstrated the significant therapeutic effects of the encoded structural color microspheres. Green moisturizing microspheres facilitate to relieve dry, flaky skin patches; blue cfDNA scavenging and red anti-inflammatory microspheres significantly reduce skin inflammation. More importantly, combination therapy with encoded microspheres exerted the synergistic effects, including the increased body weight, thicker epidermal layer, and reduced immune activation. Overall, this synergistic treatment offers a promising platform for personalized management of psoriasis and various inflammatory skin diseases.
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来源期刊
APL Materials
APL Materials NANOSCIENCE & NANOTECHNOLOGYMATERIALS SCIE-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
9.60
自引率
3.30%
发文量
199
审稿时长
2 months
期刊介绍: APL Materials features original, experimental research on significant topical issues within the field of materials science. In order to highlight research at the forefront of materials science, emphasis is given to the quality and timeliness of the work. The journal considers theory or calculation when the work is particularly timely and relevant to applications. In addition to regular articles, the journal also publishes Special Topics, which report on cutting-edge areas in materials science, such as Perovskite Solar Cells, 2D Materials, and Beyond Lithium Ion Batteries.
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