聚(乳酸羟基乙酸)-聚(乙二醇)改性人参皂苷 Rg3 纳米药物增强肝细胞癌的抗肿瘤效果

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Wei Zheng,Yuqiao Huang,Qiong Wu,Pu Cheng,Song Yujun,Ben Wang,Qi Huang,Shen Hu
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引用次数: 0

摘要

本研究旨在通过聚(乳酸羟基乙酸)-聚(乙二醇)(PLGA-PEG)的改性提高人参皂苷Rg3的生物利用度和抗肝细胞癌(HCC)的疗效。方法通过乳化获得PLGA-PEG-Rg3,并通过傅立叶变换红外光谱、扫描电镜、激光粒度分析仪和高效液相色谱法评估其理化性质。结果PLGA-PEG-Rg3的粒径为122 nm,多分散指数为0.112,具有体外持续释放特性。与 Rg3 相比,PLGA-PEG-Rg3 在体外抑制 HepG2 生长和通过线粒体凋亡途径诱导细胞凋亡方面更有效。结论总之,这些结果表明 PLGA-PEG-Rg3 增强了 Rg3 在 HCC 中的抗肿瘤作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Poly(lactic acid hydroxyacetic acid)-poly(ethylene glycol)-modified ginsenoside Rg3 nanomedicine enhances anti-tumor effect in hepatocellular carcinoma.
OBJECTIVE This research aim to improve bioavailability and anti-hepatocellular carcinoma (HCC) efficacy of Ginsenoside Rg3 by modification with poly (lactic acid hydroxyacetic acid)-poly(ethylene glycol) (PLGA-PEG). METHODS PLGA-PEG-Rg3 was obtained by emulsification and evaluated it physiochemical characterization by FTIR, SEM, laser particle-size analyser and HPLC. The effect of the PLGA-PEG-Rg3 and Rg3 on HepG2 cells was compared in vitro studies, including cell proliferation, transwell and a series of apoptosis detection, and in-situ HCC model. RESULTS The PLGA-PEG-Rg3 were 122 nm in size and 0.112 in polydispersity index with sustained release profile in vitro. Compared to Rg3, PLGA-PEG-Rg3 was more effective in suppressing HepG2 growth and inducing apoptosis by mitochondrial apoptosis pathway in vitro. and PLGA-PEG modification enhanced the liver-targeting ability and drug circulation time of Rg3 in vivo, resulting in PLGA-PEG-Rg3 possessed superior performance in inhibiting tumor growth and prolonging survival time of tumor-bearing mice than Rg3. CONCLUSIONS Overall, these results showed PLGA-PEG-Rg3 enhanced anti-tumor effect of Rg3 in HCC.
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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