椎间盘内板损伤诱发椎间盘退变的动物模型:系统回顾

IF 2.1 4区 医学 Q2 SURGERY
Yukun Ma,Xing Yu,Wenhao Li,Jianbin Guan,Ziye Qiu,Luchun Xu,Ningning Feng,Guozheng Jiang,Xinliang Yue
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引用次数: 0

摘要

目的系统回顾通过终板损伤途径诱发椎间盘退变的相关动物模型,为探索椎间盘退变的内在机制和治疗方法提供合适的动物模型。设计检索PubMed、Web of Science、Cochrane等数据库中建立至2024年8月与终板损伤途径诱发椎间盘退变动物模型相关的文献,筛选并提取文献中的关键内容,采用文献归纳法对各类动物模型进行分析和评价。结果最终收录了15篇动物实验研究文献,可分为直接损伤模型和间接损伤模型,其中直接损伤模型包括经椎体损伤模型和经关节入路损伤模型,间接损伤模型包括终板缺血模型和椎体骨折诱发终板损伤模型。直接损伤模型的观察期最短为 2 个月,最长为 32 周。所有直接损伤模型都能成功引起椎间盘退变,干预次数越多,引起的椎间盘退变程度越大。间接损伤模型的观察期从 4 周到 70 周不等。在9项研究中,只有一项研究未能成功诱发椎间盘退变,这也是本研究中首次尝试干预终板导致椎间盘退变的动物实验。结论直接损伤模型的损伤更直接,程度更可控,可有效导致椎间盘退变。间接损伤模型不直接损伤椎间盘终板结构,更易于观察椎间盘终板及相关结构的生理和病理状态。但它们都不能完全模拟人类终板损伤诱发椎间盘退变的相应过程,而且这类模型也没有统一的临床判断标准。最合适的动物模型仍需进一步探索和发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Animal Models of Internal Endplate Injury-Induced Intervertebral Disc Degeneration: A Systematic Review.
OBJECTIVE To systematically review relevant animal models of disk degeneration induced through the endplate injury pathway and to provide suitable animal models for exploring the intrinsic mechanisms and treatment of disk degeneration. DESIGN PubMed, Web of Science, Cochrane and other databases were searched for literature related to animal models of disk degeneration induced by the endplate injury pathway from establishment to August 2024, and key contents in the literature were screened and extracted to analyze and evaluate each type of animal model using the literature induction method. RESULTS Fifteen animal experimental studies were finally included in the literature, which can be categorized into direct injury models and indirect injury models, of which direct injury models include transvertebral injury models and transpedicular approach injury models, and indirect injury models include endplate ischemia models and vertebral fracture-induced endplate injury models. The direct injury models have a minimum observation period of 2 months and a maximum of 32 wk. All direct injury models were successful in causing disk degeneration, and the greater the number of interventions, the greater the degree of disk degeneration caused. The observation period for the indirect injury models varied from 4 wk to 70 wk. Of the 9 studies, only one study was unsuccessful in inducing disk degeneration, and this was the first animal study in this research to attempt to intervene on the endplate to cause disk degeneration. CONCLUSION The damage to the direct injury model is more immediate and controllable in extent and can effectively lead to disk degeneration. The indirect injury models do not directly damage the endplate structure, making it easier to observe the physiological and pathological condition of the endplate and associated structures of the disk. None of them can completely simulate the corresponding process of endplate injury-induced disk degeneration in humans, and there is no uniform clinical judgment standard for this type of model. The most appropriate animal model still needs further exploration and discovery.
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Journal of Investigative Surgery publishes peer-reviewed scientific articles for the advancement of surgery, to the ultimate benefit of patient care and rehabilitation. It is the only journal that encompasses the individual and collaborative efforts of scientists in human and veterinary medicine, dentistry, basic and applied sciences, engineering, and law and ethics. The journal is dedicated to the publication of outstanding articles of interest to the surgical research community.
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