Amber L. Gaulden, Usha D. Nagaraj, A. Scott Emmert, Shawn M. Vuong, Beth M. Kline‐Fath, Karin S. Bierbrauer, Smruti K. Patel
{"title":"基于成像的胎儿头枕部围产期发病率和死亡率预测参数","authors":"Amber L. Gaulden, Usha D. Nagaraj, A. Scott Emmert, Shawn M. Vuong, Beth M. Kline‐Fath, Karin S. Bierbrauer, Smruti K. Patel","doi":"10.1002/pd.6660","DOIUrl":null,"url":null,"abstract":"ObjectiveFetal occipital cephaloceles display significant morphologic heterogeneity resulting in variable cognitive and survival outcomes. The purpose of this study was to determine if specific imaging findings could provide predictive information on the clinical outcomes of patients with occipital cephalocele.MethodsWe conducted a retrospective review of fetal occipital cephalocele patients. Fetal and post‐natal imaging studies were evaluated for multiple parameters including: cephalocele size, ellipsoid volume, herniation of various neural tissues, and microcephaly. Based on the presence of certain findings, an imaging score (range: 0–11) and cephalocele grade (range: 0–4) were calculated.ResultsHigher fetal and post‐natal imaging scores were positively correlated with higher cephalocele grade (<jats:italic>p</jats:italic> < 0.0001). Higher cephalocele grade was positively correlated with cerebellum and occipital lobe involvement (<jats:italic>p</jats:italic> < 0.05). A higher fetal cephalocele grade was associated with a significantly high risk of mortality (CI: 15.5–22.10; <jats:italic>p</jats:italic> < 0.0001).ConclusionHigher imaging scores and cephalocele grade were associated with a greater risk of mortality and verbal and motor delays. Imaging factors that appear to play a role in increasing cephalocele grade include involvement of the cerebellum, occipital lobes, and microcephaly. These findings may help counsel parents regarding the post‐natal course of patients with occipital cephalocele.","PeriodicalId":20387,"journal":{"name":"Prenatal Diagnosis","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Imaging‐Based Prediction Parameters of Perinatal Morbidity and Mortality for Fetal Occipital Cephaloceles\",\"authors\":\"Amber L. Gaulden, Usha D. Nagaraj, A. Scott Emmert, Shawn M. Vuong, Beth M. Kline‐Fath, Karin S. Bierbrauer, Smruti K. Patel\",\"doi\":\"10.1002/pd.6660\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"ObjectiveFetal occipital cephaloceles display significant morphologic heterogeneity resulting in variable cognitive and survival outcomes. The purpose of this study was to determine if specific imaging findings could provide predictive information on the clinical outcomes of patients with occipital cephalocele.MethodsWe conducted a retrospective review of fetal occipital cephalocele patients. Fetal and post‐natal imaging studies were evaluated for multiple parameters including: cephalocele size, ellipsoid volume, herniation of various neural tissues, and microcephaly. Based on the presence of certain findings, an imaging score (range: 0–11) and cephalocele grade (range: 0–4) were calculated.ResultsHigher fetal and post‐natal imaging scores were positively correlated with higher cephalocele grade (<jats:italic>p</jats:italic> < 0.0001). Higher cephalocele grade was positively correlated with cerebellum and occipital lobe involvement (<jats:italic>p</jats:italic> < 0.05). A higher fetal cephalocele grade was associated with a significantly high risk of mortality (CI: 15.5–22.10; <jats:italic>p</jats:italic> < 0.0001).ConclusionHigher imaging scores and cephalocele grade were associated with a greater risk of mortality and verbal and motor delays. Imaging factors that appear to play a role in increasing cephalocele grade include involvement of the cerebellum, occipital lobes, and microcephaly. These findings may help counsel parents regarding the post‐natal course of patients with occipital cephalocele.\",\"PeriodicalId\":20387,\"journal\":{\"name\":\"Prenatal Diagnosis\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prenatal Diagnosis\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/pd.6660\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prenatal Diagnosis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/pd.6660","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
Imaging‐Based Prediction Parameters of Perinatal Morbidity and Mortality for Fetal Occipital Cephaloceles
ObjectiveFetal occipital cephaloceles display significant morphologic heterogeneity resulting in variable cognitive and survival outcomes. The purpose of this study was to determine if specific imaging findings could provide predictive information on the clinical outcomes of patients with occipital cephalocele.MethodsWe conducted a retrospective review of fetal occipital cephalocele patients. Fetal and post‐natal imaging studies were evaluated for multiple parameters including: cephalocele size, ellipsoid volume, herniation of various neural tissues, and microcephaly. Based on the presence of certain findings, an imaging score (range: 0–11) and cephalocele grade (range: 0–4) were calculated.ResultsHigher fetal and post‐natal imaging scores were positively correlated with higher cephalocele grade (p < 0.0001). Higher cephalocele grade was positively correlated with cerebellum and occipital lobe involvement (p < 0.05). A higher fetal cephalocele grade was associated with a significantly high risk of mortality (CI: 15.5–22.10; p < 0.0001).ConclusionHigher imaging scores and cephalocele grade were associated with a greater risk of mortality and verbal and motor delays. Imaging factors that appear to play a role in increasing cephalocele grade include involvement of the cerebellum, occipital lobes, and microcephaly. These findings may help counsel parents regarding the post‐natal course of patients with occipital cephalocele.
期刊介绍:
Prenatal Diagnosis welcomes submissions in all aspects of prenatal diagnosis with a particular focus on areas in which molecular biology and genetics interface with prenatal care and therapy, encompassing: all aspects of fetal imaging, including sonography and magnetic resonance imaging; prenatal cytogenetics, including molecular studies and array CGH; prenatal screening studies; fetal cells and cell-free nucleic acids in maternal blood and other fluids; preimplantation genetic diagnosis (PGD); prenatal diagnosis of single gene disorders, including metabolic disorders; fetal therapy; fetal and placental development and pathology; development and evaluation of laboratory services for prenatal diagnosis; psychosocial, legal, ethical and economic aspects of prenatal diagnosis; prenatal genetic counseling