优化新型海藻酸钠/蒙脱石/氧化锌仿生复合材料的合成和表征，将其作为抗变异链球菌的抗菌剂

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects Pub Date : 2024-08-31 DOI:10.1016/j.nanoso.2024.101318

Mohammad Moslem Imani, Pourya Gorji, Mohammad Salmani Mobarakeh, Mohsen Safaei

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引用次数: 0

摘要

由于细菌的抗药性不断升级，本次研究的目的是找出最有利的条件，以制造由海藻酸钠、蒙脱石和氧化锌组成的新型仿生复合材料，使其具有最大程度的抗菌功效。为了确定具有最佳抗菌活性的纳米复合材料的最佳合成条件，研究人员采用田口方法共设计了九项实验。所研究的纳米复合材料是用原位法生产的。利用菌落形成单位法评估了合成纳米复合材料的抗菌效果。由 60 毫克/毫升海藻酸盐、0.6 毫克/毫升蒙脱石和 6 毫克/毫升氧化锌合成的纳米复合材料表现出最强的抗菌活性。氧化锌因子对细菌活力的影响最大。利用各种分析方法证实了在理想条件下合成海藻酸盐/MMT/氧化锌纳米复合材料。该研究表明，海藻酸盐/MMT/氧化锌纳米复合材料在最佳条件下具有很高的性能，而且最佳含量的成分可提高合成纳米复合材料的抗菌性能。

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Optimization of synthesis and characterization of novel sodium alginate/montmorillonite/zinc oxide bionanocomposite as an antibacterial agent against Streptococcus mutans

Due to the escalating bacterial resistance, the objective of the current investigation was to discover the most favorable condition for the fabrication of a novel bionanocomposite consisting of sodium alginate, montmorillonite, and ZnO, possessing the greatest degree of antibacterial efficacy. To determine the optimal synthesis conditions for nanocomposite with the most favorable antimicrobial activity, a total of nine experiments were devised via the Taguchi methodology. The studied nanocomposites were produced using the in situ method. The antibacterial efficacy of the synthesized nanocomposites was assessed against through the utilization of the colony-forming unit methodology. The nanocomposites synthesized, consisting of 60 mg/mL alginate, 0.6 mg/mL montmorillonite, and 6 mg/mL ZnO, exhibited the most potent antibacterial activity. The greatest effect on bacterial viability was related to the ZnO factor. The synthesis of alginate/MMT/ZnO nanocomposites with desirable conditions was confirmed using various analyses. This study showed that alginate/MMT/ZnO nanocomposite has high performance under optimal conditions, and applying optimal levels of components improves the antibacterial properties of the synthesized nanocomposite.

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来源期刊

Nano-Structures & Nano-Objects Physics and Astronomy-Condensed Matter Physics

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

22 days

期刊介绍： Nano-Structures & Nano-Objects is a new journal devoted to all aspects of the synthesis and the properties of this new flourishing domain. The journal is devoted to novel architectures at the nano-level with an emphasis on new synthesis and characterization methods. The journal is focused on the objects rather than on their applications. However, the research for new applications of original nano-structures & nano-objects in various fields such as nano-electronics, energy conversion, catalysis, drug delivery and nano-medicine is also welcome. The scope of Nano-Structures & Nano-Objects involves: -Metal and alloy nanoparticles with complex nanostructures such as shape control, core-shell and dumbells -Oxide nanoparticles and nanostructures, with complex oxide/metal, oxide/surface and oxide /organic interfaces -Inorganic semi-conducting nanoparticles (quantum dots) with an emphasis on new phases, structures, shapes and complexity -Nanostructures involving molecular inorganic species such as nanoparticles of coordination compounds, molecular magnets, spin transition nanoparticles etc. or organic nano-objects, in particular for molecular electronics -Nanostructured materials such as nano-MOFs and nano-zeolites -Hetero-junctions between molecules and nano-objects, between different nano-objects & nanostructures or between nano-objects & nanostructures and surfaces -Methods of characterization specific of the nano size or adapted for the nano size such as X-ray and neutron scattering, light scattering, NMR, Raman, Plasmonics, near field microscopies, various TEM and SEM techniques, magnetic studies, etc .