{"title":"利用茉莉花叶提取物生物合成的多功能银纳米粒子的潜在体外抗菌和抗癌特性","authors":"Megha B. Abbigeri, Bothe Thokchom, Santosh Mallikarjun Bhavi, Sapam Riches Singh, Pooja Joshi, Ramesh Babu Yarajarla","doi":"10.1016/j.nanoso.2024.101320","DOIUrl":null,"url":null,"abstract":"L., a medicinal herb rich in secondary metabolites, serves as a sustainable source for synthesizing silver nanoparticles (AgNPs). This study explores the eco-friendly production of AgNPs using aqueous leaf extract from and evaluates their biomedical applications. Characterization techniques including UV-Visible spectroscopy, FT-IR, SEM, TEM, and XRD confirm the spherical shape and FCC structure of the AgNPs, with a mean size of ∼11 nm and a surface charge of −24.4 mV. Biologically, the AgNPs exhibit potent antibacterial activity against both Gram positive and Gram negative bacteria, with dosage-dependent inhibition zones. AgNPs exhibited zone of inhibition comparable to those of standard antibiotic, penicillin, against Gram positive bacteria ( 22.09 mm and 23.72 mm) and Gram negative bacteria (, 13.82 mm and , 14.81 mm). They demonstrate cytotoxicity against NIH 3T3 and MCF-7 cells, with IC of 23.46 μg mL and 19.15 μg mL in cytotoxicity and anticancer assays, respectively. Notably, fragmentation assays reveal smear formation, indicating potential for inducing apoptosis. The synthesized AgNPs from exhibit spherical morphology, moderate stability, and significant antibacterial and anticancer properties, suggesting their potential as versatile biomedical agents.","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":null,"pages":null},"PeriodicalIF":5.4500,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Potential in vitro antibacterial and anticancer properties of biosynthesized multifunctional silver nanoparticles using Martynia annua L. leaf extract\",\"authors\":\"Megha B. Abbigeri, Bothe Thokchom, Santosh Mallikarjun Bhavi, Sapam Riches Singh, Pooja Joshi, Ramesh Babu Yarajarla\",\"doi\":\"10.1016/j.nanoso.2024.101320\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"L., a medicinal herb rich in secondary metabolites, serves as a sustainable source for synthesizing silver nanoparticles (AgNPs). This study explores the eco-friendly production of AgNPs using aqueous leaf extract from and evaluates their biomedical applications. Characterization techniques including UV-Visible spectroscopy, FT-IR, SEM, TEM, and XRD confirm the spherical shape and FCC structure of the AgNPs, with a mean size of ∼11 nm and a surface charge of −24.4 mV. Biologically, the AgNPs exhibit potent antibacterial activity against both Gram positive and Gram negative bacteria, with dosage-dependent inhibition zones. AgNPs exhibited zone of inhibition comparable to those of standard antibiotic, penicillin, against Gram positive bacteria ( 22.09 mm and 23.72 mm) and Gram negative bacteria (, 13.82 mm and , 14.81 mm). They demonstrate cytotoxicity against NIH 3T3 and MCF-7 cells, with IC of 23.46 μg mL and 19.15 μg mL in cytotoxicity and anticancer assays, respectively. Notably, fragmentation assays reveal smear formation, indicating potential for inducing apoptosis. The synthesized AgNPs from exhibit spherical morphology, moderate stability, and significant antibacterial and anticancer properties, suggesting their potential as versatile biomedical agents.\",\"PeriodicalId\":397,\"journal\":{\"name\":\"Nano-Structures & Nano-Objects\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.4500,\"publicationDate\":\"2024-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nano-Structures & Nano-Objects\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://doi.org/10.1016/j.nanoso.2024.101320\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Physics and Astronomy\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano-Structures & Nano-Objects","FirstCategoryId":"1","ListUrlMain":"https://doi.org/10.1016/j.nanoso.2024.101320","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Physics and Astronomy","Score":null,"Total":0}
Potential in vitro antibacterial and anticancer properties of biosynthesized multifunctional silver nanoparticles using Martynia annua L. leaf extract
L., a medicinal herb rich in secondary metabolites, serves as a sustainable source for synthesizing silver nanoparticles (AgNPs). This study explores the eco-friendly production of AgNPs using aqueous leaf extract from and evaluates their biomedical applications. Characterization techniques including UV-Visible spectroscopy, FT-IR, SEM, TEM, and XRD confirm the spherical shape and FCC structure of the AgNPs, with a mean size of ∼11 nm and a surface charge of −24.4 mV. Biologically, the AgNPs exhibit potent antibacterial activity against both Gram positive and Gram negative bacteria, with dosage-dependent inhibition zones. AgNPs exhibited zone of inhibition comparable to those of standard antibiotic, penicillin, against Gram positive bacteria ( 22.09 mm and 23.72 mm) and Gram negative bacteria (, 13.82 mm and , 14.81 mm). They demonstrate cytotoxicity against NIH 3T3 and MCF-7 cells, with IC of 23.46 μg mL and 19.15 μg mL in cytotoxicity and anticancer assays, respectively. Notably, fragmentation assays reveal smear formation, indicating potential for inducing apoptosis. The synthesized AgNPs from exhibit spherical morphology, moderate stability, and significant antibacterial and anticancer properties, suggesting their potential as versatile biomedical agents.
期刊介绍:
Nano-Structures & Nano-Objects is a new journal devoted to all aspects of the synthesis and the properties of this new flourishing domain. The journal is devoted to novel architectures at the nano-level with an emphasis on new synthesis and characterization methods. The journal is focused on the objects rather than on their applications. However, the research for new applications of original nano-structures & nano-objects in various fields such as nano-electronics, energy conversion, catalysis, drug delivery and nano-medicine is also welcome. The scope of Nano-Structures & Nano-Objects involves: -Metal and alloy nanoparticles with complex nanostructures such as shape control, core-shell and dumbells -Oxide nanoparticles and nanostructures, with complex oxide/metal, oxide/surface and oxide /organic interfaces -Inorganic semi-conducting nanoparticles (quantum dots) with an emphasis on new phases, structures, shapes and complexity -Nanostructures involving molecular inorganic species such as nanoparticles of coordination compounds, molecular magnets, spin transition nanoparticles etc. or organic nano-objects, in particular for molecular electronics -Nanostructured materials such as nano-MOFs and nano-zeolites -Hetero-junctions between molecules and nano-objects, between different nano-objects & nanostructures or between nano-objects & nanostructures and surfaces -Methods of characterization specific of the nano size or adapted for the nano size such as X-ray and neutron scattering, light scattering, NMR, Raman, Plasmonics, near field microscopies, various TEM and SEM techniques, magnetic studies, etc .