新型荧光探针：用于高效检测活体动植物组织中的氟离子

IF 2.6 3区化学 Q2 CHEMISTRY, ANALYTICAL

Analytical Methods Pub Date : 2024-09-06 DOI:10.1039/D4AY01407C

Jun Chen, Maoting Qu, Jiahao Zhang, Yongxue Yao, Xinyu Pei, Wen Wu and Shuchen Pei

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引用次数: 0

摘要

本课题介绍了一种用于氟离子特异性检测的新型荧光探针 IF-Br-F 的设计与合成。探针 IF-Br-F 具有优异的荧光特性，并通过 HRMS 和 DFT 计算成功验证了探针对氟离子的响应机制。IF-Br-F 具有高灵敏度和低检测限（5.82×10-7 mol/L），可成功检测实际水样中的氟离子。该探针可用于斑马鱼、细胞和拟南芥根系的荧光成像，具有低细胞毒性和良好的生物相容性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A novel fluorescent probe for efficient detection of fluoride ions in living animal and plant tissues†

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A novel fluorescent probe for efficient detection of fluoride ions in living animal and plant tissues†

This work presents the design and synthesis of a new fluorescent probe IF-Br-F for the specific detection of fluoride ions. The IF-Br-F probe has excellent fluorescence properties, and the mechanism of the probe response to fluoride ions was successfully verified via HRMS and DFT calculations. IF-Br-F has high sensitivity and low detection limit (5.82 × 10⁻⁷ mol L⁻¹) and successfully detects fluoride ions in actual water samples. The probe can be applied to fluorescence imaging of zebrafish, cells, and Arabidopsis roots and exhibits low cytotoxicity and good biocompatibility.

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