通过 Mn2+ 触发左旋多巴荧光共聚物纳米粒子的聚集诱导发射转变实现的原位比率计荧光免疫传感器

IF 2.6 3区化学 Q2 CHEMISTRY, ANALYTICAL

Analytical Methods Pub Date : 2024-09-10 DOI:10.1039/D4AY00973H

Yifei Ma, Xiaoxue Liu, Naidi Yang, Changpeng Zou, Yujie Sun, Guichuan Xing, Jinhua Liu, Zhihui Xu and Fenghua Geng

{"title":"通过 Mn2+ 触发左旋多巴荧光共聚物纳米粒子的聚集诱导发射转变实现的原位比率计荧光免疫传感器","authors":"Yifei Ma, Xiaoxue Liu, Naidi Yang, Changpeng Zou, Yujie Sun, Guichuan Xing, Jinhua Liu, Zhihui Xu and Fenghua Geng","doi":"10.1039/D4AY00973H","DOIUrl":null,"url":null,"abstract":"Herein, a direct in situ alkaline phosphatase (ALP)-labeled luminescent nanoimmunoassay platform was constructed using Mn2+-triggered aggregation-induced emission transformation of levodopa fluorescent copolymer (LFC) nanoparticles. Using cardiac troponin I (cTn I) as the model antigen, the proposed nanoimmunosensor has been applied to detect cTn I in clinical samples with satisfactory results.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 39","pages":" 6676-6680"},"PeriodicalIF":2.6000,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An in situ ratiometric fluorescence immunosensor via Mn2+-triggered aggregation-induced emission transformation of levodopa fluorescent copolymer nanoparticles†\",\"authors\":\"Yifei Ma, Xiaoxue Liu, Naidi Yang, Changpeng Zou, Yujie Sun, Guichuan Xing, Jinhua Liu, Zhihui Xu and Fenghua Geng\",\"doi\":\"10.1039/D4AY00973H\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Herein, a direct in situ alkaline phosphatase (ALP)-labeled luminescent nanoimmunoassay platform was constructed using Mn2+-triggered aggregation-induced emission transformation of levodopa fluorescent copolymer (LFC) nanoparticles. Using cardiac troponin I (cTn I) as the model antigen, the proposed nanoimmunosensor has been applied to detect cTn I in clinical samples with satisfactory results.\",\"PeriodicalId\":64,\"journal\":{\"name\":\"Analytical Methods\",\"volume\":\" 39\",\"pages\":\" 6676-6680\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Analytical Methods\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2024/ay/d4ay00973h\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical Methods","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/ay/d4ay00973h","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}

引用次数: 0

摘要

本文利用 Mn2+ 触发左旋多巴荧光共聚物（LFC）纳米颗粒的聚集诱导发射转化，构建了一种直接原位碱性磷酸酶（ALP）标记发光纳米免疫分析平台。该纳米免疫传感器以心肌肌钙蛋白 I（cTn I）为模型抗原，用于检测临床样本中的 cTn I，结果令人满意。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

An in situ ratiometric fluorescence immunosensor via Mn2+-triggered aggregation-induced emission transformation of levodopa fluorescent copolymer nanoparticles†

查看原文本刊更多论文

An in situ ratiometric fluorescence immunosensor via Mn2+-triggered aggregation-induced emission transformation of levodopa fluorescent copolymer nanoparticles†

Herein, a direct in situ alkaline phosphatase (ALP)-labeled luminescent nanoimmunoassay platform was constructed using Mn²⁺-triggered aggregation-induced emission transformation of levodopa fluorescent copolymer (LFC) nanoparticles. Using cardiac troponin I (cTn I) as the model antigen, the proposed nanoimmunosensor has been applied to detect cTn I in clinical samples with satisfactory results.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊