通过方差数量性状位点改进维生素 D 基因与环境相互作用的特征描述

medRxiv - Genetic and Genomic Medicine Pub Date : 2024-08-31 DOI:10.1101/2024.08.30.24312868

Tianyuan Lu, Wenmin Zhang, Cassianne Robinson-Cohen, Corinne D. Engelman, Qiongshi Lu, Ian H. de Boer, Lei Sun, Andrew D. Paterson

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摘要

背景了解影响维生素 D 状态的基因-环境互作效应可完善针对维生素 D 缺乏症的营养和公共卫生策略。近年来方法学的进步使得基因与环境互作效应富集的变异数量性状位点（vQTLs）的鉴定成为可能。

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Improved characterization of gene-environment interactions for vitamin D through variance quantitative trait loci

Background Understanding gene-environment interaction effects influencing vitamin D status may refine nutrition and public health strategies for vitamin D deficiency. Recent methodological advances have enabled the identification of variance quantitative trait loci (vQTLs) where gene-environment interaction effects are enriched.

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medRxiv - Genetic and Genomic Medicine

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