medRxiv - Genetic and Genomic Medicine

Exome wide association study for blood lipids in 1,158,017 individuals from diverse populations

Pub Date : 2024-09-18 DOI: 10.1101/2024.09.17.24313718 Satoshi Koyama, Zhi Yu, Seung Hoan Choi, Sean J. Jurgens, Margaret Sunitha Selvaraj, Derek Klarin, Jennifer E. Huffman, Shoa L. Clarke, Michael N. Trinh, Akshaya Ravi, Jacqueline S. Dron, Catherine Spinks, Ida Surakka, Aarushi Bhatnagar, Kim Lannery, Whitney Hornsby, Scott M. Damrauer, Kyong-Mi Chang, Julie A. Lynch, Themistocles L. Assimes, Philip S. Tsao, Daniel J. Rader, Kelly Cho, Gina M. Peloso, Patrick T. Ellinor, Yan V. Sun, Peter WF. Wilson, The Million Veteran Program, Pradeep Natarajan

Identifying individuals at risk for surgical supravalvar aortic stenosis by polygenic risk score with graded phenotyping

Pub Date : 2024-09-18 DOI: 10.1101/2024.09.17.24313555 Delong Liu, Carolyn Beth Mervis, Mark Levin, Elisa Biamino, Maria Francesca Bedeschi, Maria Cristina Digilio, Gabriella Maria Squeo, Roberta Villa, Neelam Raja, Joy Lynne Freeman, Sharon Osgood, Giuseppe Merla, Amy Roberts, Colleen Morris, Lucy R Osborne, Beth Kozel

Deciphering the functional impact of Alzheimers Disease-associated variants in resting and proinflammatory immune cells

Pub Date : 2024-09-16 DOI: 10.1101/2024.09.13.24313654 Marielle L Bond, I Yoseli Quiroga-Barber, Susan D'Costa, Yijia Wu, Jessica Bell, Jessica McAfee, Nicole Kramer, Sool Lee, Mary Patrucco, Douglas Phanstiel, Hyejung Won