改良超声波辅助共沉淀法表征磁性锌铁氧体纳米粒子的多功能性和抗癌特性

IF 1.8 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

ECS Journal of Solid State Science and Technology Pub Date : 2024-08-30 DOI:10.1149/2162-8777/ad71f2

K. Ashok, P. Usha, Nagaraju R., T. Ramesh, N. Pavan Kumar, Ghassan M. Sulaiman

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引用次数: 0

摘要

通过改良超声辅助共沉淀法成功合成了锌铁氧体（ZnFe2O4）纳米粒子。通过 X 射线衍射 (XRD) 分析和里特维尔德细化法进行的结构表征显示，该纳米粒子为具有混合尖晶石结构的单立方相。傅立叶变换红外光谱分析证实了尖晶石铁氧体结构中官能团的存在。利用场发射扫描电子显微镜进行的形态分析表明，纳米颗粒的形态和尺寸分布均匀一致。紫外-可见光谱显示了其光学特性，而陶氏图谱法则确定了其光带隙。电子顺磁共振光谱证实了线宽为 1254 Oe 的对称共振峰和 2.133 的 Lande g 值。磁滞回线证实了纳米粒子的软磁性质，其磁饱和度和矫顽力分别为 39.2 emu gm-1 和 77.5 Oe。针对各种癌细胞系（HeLa、HepG-2 和 MCF-7）的抗癌特性表明，与 MCF-7 癌细胞相比，HepG-2 和 HeLa 细胞具有显著的抗癌活性，并将结果与标准药物顺铂进行了比较。对不同癌细胞系的结果进行了比较分析和讨论。

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Multifunctional Characterization and Anticancer Properties of Magnetic Zinc Ferrite Nanoparticles by Modified Ultrasonic Assisted Co-precipitation Method

Zinc Ferrite (ZnFe₂O₄) nanoparticles were synthesized successfully via the modified ultrasonic-assisted co-precipitation method. Structural characterization, conducted through X-ray diffraction (XRD) analysis and Rietveld refinement, revealed a single cubic phase with a mixed spinel structure. Fourier transform infrared spectroscopy confirmed the presence of functional groups indicative of the spinel ferrite structure. Morphological analysis using field-emission scanning electron microscopy showcased the nanoparticles’ uniform morphology and size distribution. UV–vis spectra revealed the optical properties, while the Tauc Plot method determined the optical band gap. Electron paramagnetic resonance spectra confirm the symmetric resonance peak with 1254 Oe line width and the Lande g value 2.133. Magnetic hysteresis loops confirm the soft magnetic nature of the nanoparticles with magnetic saturation and coercivity of 39.2 emu gm⁻¹ and 77.5 Oe. The anticancer properties against various cancer cell lines (HeLa, HepG-2 and MCF-7) revealed significant anticancer activity against HepG-2 and HeLa cells compared to MCF-7 cancer cells, and the results were compared with the standard drug cisplatin. A comparative analysis of results among cancer cell lines was conducted and discussed.

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来源期刊

ECS Journal of Solid State Science and Technology MATERIALS SCIENCE, MULTIDISCIPLINARY-PHYSICS, APPLIED

CiteScore

4.50

自引率

13.60%

发文量

455

期刊介绍： The ECS Journal of Solid State Science and Technology (JSS) was launched in 2012, and publishes outstanding research covering fundamental and applied areas of solid state science and technology, including experimental and theoretical aspects of the chemistry and physics of materials and devices. JSS has five topical interest areas: carbon nanostructures and devices dielectric science and materials electronic materials and processing electronic and photonic devices and systems luminescence and display materials, devices and processing.