Evaluation and analysis of dynamic contrast-enhanced magnetic resonance imaging quantitative parameters in assessing therapeutic efficacy and pathological typing of patients with cervical cancer undergoing neoadjuvant chemotherapy

It was to demonstrate the therapeutic effects of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) quantitative parameters (QPs) in cervical cancer (CC) patients undergoing neoadjuvant chemotherapy (NACT) and their role in evaluating pathological characteristics. Fifty CC patients were selected as CC group, received NACT, and underwent DCE-MRI scans pre- and post-treatment. Fifty normal cervical subjects were collected as Ctrl group. DCE-MRI QPs (K, K, V) of both groups were analyzed, along with changes in CC group before and after NACT, pathological subtypes, tumor differentiation degree, clinical staging, lymph node metastasis, and vascular invasion. The relationship between QPs and the pathological features was analyzed. The K, K, and V of CC group notably exceeded those of Ctrl group. The tumor shrinkage rate was positively correlated with the values of K, K, and V. The K value of squamous cell carcinoma (SCC) patients markedly exceeded that of adenocarcinoma patients. The K and K values of poorly differentiated tumors notably exceeded those of moderately/highly differentiated tumors. The K, K, and V values of stage IIb/III tumors notably exceeded those of stage I/Ia tumors, with all differences being considerable ( < 0.05). QPs differed inconsiderably between the two groups regarding lymph node metastasis and vascular invasion ( > 0.05). DCE-MRI QPs effectively reflect the vascular characteristics and hemodynamic changes of CC, and have evaluation value for the pathological subtypes, differentiation degree, and clinical staging of CC.