基于 1,2,4-三酮的多官能化嘧啶

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2024-08-31 DOI:10.1007/s11172-024-4316-5

Yu. O. Edilova, E. A. Osipova, Yu. S. Kudyakova, P. A. Slepukhin, V. I. Saloutin, D. N. Bazhin

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引用次数: 0

摘要

我们开发了一种基于 1,2,4-三酮类似物合成多官能团化嘧啶的方法。在乙腈中过量的 (EtO)3B/Et3N 存在下，乙缩醛取代的 β-二酮参与了与脒的缩合。研究发现，含缩醛嘧啶的酸水解条件取决于重氮中取代基的性质。使用 1,2,4-三酮与脒缩合，可一步合成乙酰基嘧啶。

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Polyfunctionalized pyrimidines based on 1,2,4-triketones

An approach was developed for the synthesis of polyfunctionalized pyrimidines based on analogs of 1,2,4-triketones. Acetal-substituted β-diketones are involved in the condensation with amidines in the presence of an excess of (EtO)₃B/Et₃N in acetonitrile. The conditions of the acid hydrolysis of acetal-containing pyrimidines were found to depend on the nature of substituents in diazine. The use of 1,2,4-triketone in the condensation with amidine allows the synthesis of acetylpyrimidine in one step.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.