N-(2-羧基苯基)草酰胺在合成喹唑啉类中枢神经系统抑制剂甲喹酮和融合生物杂环系统中的应用

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2024-08-31 DOI:10.1007/s11172-024-4319-2

V. L. Mamedova, T. A. Kushatov, N. A. Tikhomirova, O. G. Sinyashin, V. A. Mamedov

引用次数: 0

摘要

开发了一种从 N-(2-羧基苯基)草酰胺合成喹唑啉-4-酮类药剂甲喹酮的方法。提出了一种将 3-(2-硝基苯基)喹唑啉-4-酮还原环化为苯并咪唑并[2,1-b]喹唑啉-12(6H)-酮（天然生物碱色黄嘌呤的 6-脱氧-6-氮杂类似物）的新方法，并合成了难以获得的喹喔啉喹唑啉酮融合体系的新衍生物。

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N-(2-Carboxyphenyl)oxalamides in the synthesis of the quinazoline central nervous system depressant methaqualone and fused biheterocyclic systems

A synthesis of the quinazolin-4-one pharmacological agent methaqualone from N-(2-carboxyphenyl)oxalamide was developed. A new method for the reductive cyclization of 3-(2-nitrophenyl)quinazolin-4-ones to benzimidazo[2,1-b]quinazolin-12(6H)-ones, the 6-deoxo-6-aza analogs of natural alkaloid tryptanthrine, was suggested and new derivatives of poorly available quinoxalinoquinazolinone fused system were synthesized.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.