四只狗的环孢素诱发银屑病样皮炎:使用抗生素和减少环孢素用量获得成功治疗

IF 0.3 Q4 VETERINARY SCIENCES
Junko Ike, Ryosuke Ueda, Takeshi Mukosaka, Maiko Sekiguchi, Toshiroh Iwasaki
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引用次数: 0

摘要

四只狗连续 7-10 个月服用环孢素,剂量为 8.6-17.5 毫克/千克/天,以治疗免疫介导疾病。这些狗出现了多发性、环状苔藓样斑块,伴有红斑和色素沉着;此外,眼周、口腔和耳廓内出现了厚厚的鳞屑,并扩散到几乎全身。根据组织病理学检查和用药史,这四只狗被诊断为环孢素诱发的银屑病样鳞屑性皮肤病。四只狗中有三只在全身使用抗生素并减少环孢素用量后,皮损明显好转或消失;另一只狗在全身使用抗生素后,皮损消失。环孢素诱发的银屑病样鳞屑性皮肤病被认为是多因素的,涉及免疫系统和皮肤上的常驻球菌。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cyclosporine‐induced psoriasiform‐lichenoid dermatosis in four dogs: Successful treatment with antibiotics and cyclosporine dosage reduction
Four dogs received cyclosporine at dosages of 8.6–17.5 mg/kg/day for 7–10 months to treat immune‐mediated diseases. These dogs developed multiple, well‐circumscribed lichenoid plaques with erythema and hyperpigmentation; additionally, thick scales appeared around the eyes, mouth and inside the auricles, and spread to almost the entire body. On the basis of histopathological examination and medication history, the four dogs were diagnosed with cyclosporin‐induced psoriasiform‐lichenoid dermatosis. Three of the four dogs exhibited marked improvement or disappearance of the skin lesions after systemic administration of antibiotics and reduction of the cyclosporine dosage; in the other dog, the lesions disappeared after systemic administration of antibiotics. Cyclosporine‐induced psoriasiform‐lichenoid dermatosis is believed to be multifactorial, involving the immune system and resident cocci on the skin.
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来源期刊
Veterinary Record Case Reports
Veterinary Record Case Reports Veterinary-Veterinary (all)
CiteScore
0.50
自引率
33.30%
发文量
266
期刊介绍: Vet Record Case Reports is an online resource that publishes articles in all fields of veterinary medicine and surgery so that veterinary professionals, researchers and others can easily find important information on both common and rare conditions. Articles may be about a single animal, herd, flock or other group of animals managed together. Common cases that present a diagnostic, ethical or management challenge, or that highlight aspects of mechanisms of injury, pharmacology or histopathology are deemed of particular educational value. All articles are peer reviewed and copy edited before publication.
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