{"title":"四只狗的环孢素诱发银屑病样皮炎:使用抗生素和减少环孢素用量获得成功治疗","authors":"Junko Ike, Ryosuke Ueda, Takeshi Mukosaka, Maiko Sekiguchi, Toshiroh Iwasaki","doi":"10.1002/vrc2.984","DOIUrl":null,"url":null,"abstract":"Four dogs received cyclosporine at dosages of 8.6–17.5 mg/kg/day for 7–10 months to treat immune‐mediated diseases. These dogs developed multiple, well‐circumscribed lichenoid plaques with erythema and hyperpigmentation; additionally, thick scales appeared around the eyes, mouth and inside the auricles, and spread to almost the entire body. On the basis of histopathological examination and medication history, the four dogs were diagnosed with cyclosporin‐induced psoriasiform‐lichenoid dermatosis. Three of the four dogs exhibited marked improvement or disappearance of the skin lesions after systemic administration of antibiotics and reduction of the cyclosporine dosage; in the other dog, the lesions disappeared after systemic administration of antibiotics. Cyclosporine‐induced psoriasiform‐lichenoid dermatosis is believed to be multifactorial, involving the immune system and resident cocci on the skin.","PeriodicalId":23496,"journal":{"name":"Veterinary Record Case Reports","volume":null,"pages":null},"PeriodicalIF":0.3000,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cyclosporine‐induced psoriasiform‐lichenoid dermatosis in four dogs: Successful treatment with antibiotics and cyclosporine dosage reduction\",\"authors\":\"Junko Ike, Ryosuke Ueda, Takeshi Mukosaka, Maiko Sekiguchi, Toshiroh Iwasaki\",\"doi\":\"10.1002/vrc2.984\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Four dogs received cyclosporine at dosages of 8.6–17.5 mg/kg/day for 7–10 months to treat immune‐mediated diseases. These dogs developed multiple, well‐circumscribed lichenoid plaques with erythema and hyperpigmentation; additionally, thick scales appeared around the eyes, mouth and inside the auricles, and spread to almost the entire body. On the basis of histopathological examination and medication history, the four dogs were diagnosed with cyclosporin‐induced psoriasiform‐lichenoid dermatosis. Three of the four dogs exhibited marked improvement or disappearance of the skin lesions after systemic administration of antibiotics and reduction of the cyclosporine dosage; in the other dog, the lesions disappeared after systemic administration of antibiotics. Cyclosporine‐induced psoriasiform‐lichenoid dermatosis is believed to be multifactorial, involving the immune system and resident cocci on the skin.\",\"PeriodicalId\":23496,\"journal\":{\"name\":\"Veterinary Record Case Reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.3000,\"publicationDate\":\"2024-08-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary Record Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/vrc2.984\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary Record Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/vrc2.984","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Cyclosporine‐induced psoriasiform‐lichenoid dermatosis in four dogs: Successful treatment with antibiotics and cyclosporine dosage reduction
Four dogs received cyclosporine at dosages of 8.6–17.5 mg/kg/day for 7–10 months to treat immune‐mediated diseases. These dogs developed multiple, well‐circumscribed lichenoid plaques with erythema and hyperpigmentation; additionally, thick scales appeared around the eyes, mouth and inside the auricles, and spread to almost the entire body. On the basis of histopathological examination and medication history, the four dogs were diagnosed with cyclosporin‐induced psoriasiform‐lichenoid dermatosis. Three of the four dogs exhibited marked improvement or disappearance of the skin lesions after systemic administration of antibiotics and reduction of the cyclosporine dosage; in the other dog, the lesions disappeared after systemic administration of antibiotics. Cyclosporine‐induced psoriasiform‐lichenoid dermatosis is believed to be multifactorial, involving the immune system and resident cocci on the skin.
期刊介绍:
Vet Record Case Reports is an online resource that publishes articles in all fields of veterinary medicine and surgery so that veterinary professionals, researchers and others can easily find important information on both common and rare conditions. Articles may be about a single animal, herd, flock or other group of animals managed together. Common cases that present a diagnostic, ethical or management challenge, or that highlight aspects of mechanisms of injury, pharmacology or histopathology are deemed of particular educational value. All articles are peer reviewed and copy edited before publication.