基孔肯雅病毒基因组中的宿主适应性突变。

IF 5.5 1区 农林科学 Q1 IMMUNOLOGY
Xinhang Ning,Binghui Xia,Jiaqi Wang,Rong Gao,Hao Ren
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引用次数: 0

摘要

基孔肯雅病毒(CHIKV)是基孔肯雅热(CHIKF)的病原体,其主要传播媒介是埃及伊蚊和白纹伊蚊。基孔肯雅病毒最初在非洲流行,但近年来已在全球蔓延,影响了数百万人。根据世界卫生组织的风险评估,CHIKV 有可能严重影响公众健康。越来越多的研究表明,CHIKV 基因突变提高了病毒在宿主体内的适应能力,是导致 CHIKF 在全球流行的原因之一。本文回顾了在自然进化和实验室传播条件下 CHIKV 的宿主适应性基因突变,这有助于加深我们对 CHIKV 适应性进化的理解,并为未来 CHIKV 爆发的监测和预警提供依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Host-adaptive mutations in Chikungunya virus genome.
Chikungunya virus (CHIKV) is the causative agent of chikungunya fever (CHIKF), and its primary vectors are the mosquitoes Aedes aegypti and Aedes albopictus. CHIKV was initially endemic to Africa but has spread globally in recent years and affected millions of people. According to a risk assessment by the World Health Organization, CHIKV has the potential seriously impact public health. A growing body of research suggests that mutations in the CHIKV gene that enhance viral fitness in the host are contributing to the expansion of the global CHIKF epidemic. In this article, we review the host-adapted gene mutations in CHIKV under natural evolution and laboratory transmission conditions, which can help improve our understanding of the adaptive evolution of CHIKV and provide a basis for monitoring and early warning of future CHIKV outbreaks.
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来源期刊
Virulence
Virulence IMMUNOLOGY-MICROBIOLOGY
CiteScore
9.20
自引率
1.90%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Virulence is a fully open access peer-reviewed journal. All articles will (if accepted) be available for anyone to read anywhere, at any time immediately on publication. Virulence is the first international peer-reviewed journal of its kind to focus exclusively on microbial pathogenicity, the infection process and host-pathogen interactions. To address the new infectious challenges, emerging infectious agents and antimicrobial resistance, there is a clear need for interdisciplinary research.
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