通过三组份苯并吡喃法异氰酸酯引导合成间位苯乙烯类化合物

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2024-09-02 DOI:10.3762/bjoc.20.188

Andrey R. Galeev, Maksim V. Dmitriev, Alexander S. Novikov, Andrey N. Maslivets

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引用次数: 0

摘要

摘要从杂环取代的 1,3-二酮中开发出了一种一锅三组份合成取代的元苯胺的方法。1,3- 二酮中杂环取代基的吸电子能力（可根据计算的哈米特常数估算）在所研究的反应中起着关键作用。所制备的一系列元香豆酰苯胺（分离收率为 21–85%）证明了所开发方法的合成实用性。Chem.2024, 20, 2208–2216. doi:10.3762/bjoc.20.188

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Heterocycle-guided synthesis of m-hetarylanilines via three-component benzannulation

Abstract

A one-pot three-component synthesis of substituted meta-hetarylanilines from heterocycle-substituted 1,3-diketones has been developed. The electron-withdrawing power of the heterocyclic substituent (which can be estimated on the basis of calculated Hammett constants) in the 1,3-diketone plays a pivotal role in the studied reaction. The series of meta-hetarylanilines prepared (21–85% isolated yield) demonstrates the synthetic utility of the developed method.

Beilstein J. Org. Chem. 2024, 20, 2208–2216. doi:10.3762/bjoc.20.188

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

期刊介绍： The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.