gem-使用布氏酸/Bu4NBF4 或电生酸对碳-碳三键进行二氟化反应

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2024-09-06 DOI:10.3762/bjoc.20.194

Mizuki Yamaguchi, Hiroki Shimao, Kengo Hamasaki, Keiji Nishiwaki, Shigenori Kashimura, Kouichi Matsumoto

引用次数: 0

摘要

摘要利用 Brønsted 酸，如 Tf2NH 和 TfOH，结合 Bu4NBF4 作为氟源，进行了碳–碳三键的二氟化反应。含有炔基质的 Bu4NBF4/CH2Cl2 溶液的电化学氧化也能得到相应的二氟化宝石化合物（池内法）。电池外电解法也适用于炔烃的宝石二氟化。Chem.2024, 20, 2261–2269. doi:10.3762/bjoc.20.194

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gem-Difluorination of carbon–carbon triple bonds using Brønsted acid/Bu4NBF4 or electrogenerated acid

Abstract

gem-Difluorination of carbon–carbon triple bonds was conducted using Brønsted acids, such as Tf₂NH and TfOH, combined with Bu₄NBF₄ as the fluorine source. The electrochemical oxidation of a Bu₄NBF₄/CH₂Cl₂ solution containing alkyne substrates could also give the corresponding gem-difluorinated compounds (in-cell method). The ex-cell electrolysis method was also applicable for gem-difluorination of alkynes.

Beilstein J. Org. Chem. 2024, 20, 2261–2269. doi:10.3762/bjoc.20.194

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

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