利用氧化锌纳米颗粒和多壁碳纳米管修饰的碳浆电极,通过差分脉冲伏安法高灵敏检测茶碱

IF 2.2 4区 化学 Q2 Engineering
Yuanzheng Zhu, Yuedie Zhang, Xinyu Hao, Qiang Xia, Shuping Zhang
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引用次数: 0

摘要

茶碱是一种甲基黄嘌呤衍生物,存在于各种食物中,是一种广泛使用的支气管扩张药物。采用灵敏、低成本、快速的检测技术来检测茶碱具有重要意义。本研究采用简单的方法制备了氧化锌(ZnO)纳米颗粒和多壁碳纳米管(MWCNTs)共修饰碳浆电极(CPE),并成功地将其应用于茶碱的检测。使用循环伏安法(CV)和差分脉冲伏安法(DPV)对修饰电极的电化学行为进行了研究。与裸 CPE 和 MWCNTs/CPE 相比,ZnO 改性 MWCNTs/CPE 电极(ZnO/MWCNTs/CPE)对茶碱的电化学反应具有良好的促进作用。在优化的实验条件下,差分脉冲伏安法峰值电流与茶碱浓度在 3.3 × 10-7-1.3 × 10-4 M 范围内呈线性关系,因此可用于检测 TP;检测限为 8.3 × 10-8 M(S/N = 3),灵敏度为 0.12048 μA μM-1。此外,所制备的传感器对茶碱的测定具有高灵敏度、良好的选择性和稳定性。最后,我们用制备的电极作为实际样品,测定了药物制剂中的茶碱含量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Highly sensitive detection of theophylline by differential pulse voltammetry using zinc oxide nanoparticles and multiwalled carbon nanotubes-modified carbon paste electrode

Highly sensitive detection of theophylline by differential pulse voltammetry using zinc oxide nanoparticles and multiwalled carbon nanotubes-modified carbon paste electrode

Highly sensitive detection of theophylline by differential pulse voltammetry using zinc oxide nanoparticles and multiwalled carbon nanotubes-modified carbon paste electrode

Theophylline is a kind of methyl xanthine derivative that can be found in various foods and is a widely used bronchodilator drug. It is significant to detect theophylline by a sensitive, low-cost, and rapid determination technique. In the investigation, zinc oxide (ZnO) nanoparticles and multiwalled carbon nanotubes (MWCNTs) co-modified carbon paste electrode (CPE) was fabricated by a simple procedure and then was successfully applied to determine theophylline. The electrochemical behavior of the modified electrode was explored using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Compared with the bare CPE and MWCNTs/CPE, the ZnO-modified MWCNTs/CPE electrode (ZnO/MWCNTs/CPE) exhibited good promoting effect on the electrochemical reaction of theophylline. Under the optimized experimental statuses, the differential pulse voltammetric peak currents can be used to detect TP, since it had a linear relationship with the theophylline concentration in the range of 3.3 × 10−7–1.3 × 10−4 M. The detection limit is 8.3 × 10−8 M (S/N = 3), and the sensitivity is 0.12048 μA μM−1. Furthermore, the fabricated sensor shows high sensitivity, good selectivity, and good stability toward theophylline determination. Finally, we used the prepared electrode as an actual sample to the determination of theophylline in pharmaceutical formulations.

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来源期刊
Chemical Papers
Chemical Papers Chemical Engineering-General Chemical Engineering
CiteScore
3.30
自引率
4.50%
发文量
590
期刊介绍: Chemical Papers is a peer-reviewed, international journal devoted to basic and applied chemical research. It has a broad scope covering the chemical sciences, but favors interdisciplinary research and studies that bring chemistry together with other disciplines.
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