{"title":"利用氧化锌纳米颗粒和多壁碳纳米管修饰的碳浆电极,通过差分脉冲伏安法高灵敏检测茶碱","authors":"Yuanzheng Zhu, Yuedie Zhang, Xinyu Hao, Qiang Xia, Shuping Zhang","doi":"10.1007/s11696-024-03557-5","DOIUrl":null,"url":null,"abstract":"<div><p>Theophylline is a kind of methyl xanthine derivative that can be found in various foods and is a widely used bronchodilator drug. It is significant to detect theophylline by a sensitive, low-cost, and rapid determination technique. In the investigation, zinc oxide (ZnO) nanoparticles and multiwalled carbon nanotubes (MWCNTs) co-modified carbon paste electrode (CPE) was fabricated by a simple procedure and then was successfully applied to determine theophylline. The electrochemical behavior of the modified electrode was explored using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Compared with the bare CPE and MWCNTs/CPE, the ZnO-modified MWCNTs/CPE electrode (ZnO/MWCNTs/CPE) exhibited good promoting effect on the electrochemical reaction of theophylline. Under the optimized experimental statuses, the differential pulse voltammetric peak currents can be used to detect TP, since it had a linear relationship with the theophylline concentration in the range of 3.3 × 10<sup>−7</sup>–1.3 × 10<sup>−4</sup> M. The detection limit is 8.3 × 10<sup>−8</sup> M (<i>S/N</i> = 3), and the sensitivity is 0.12048 μA μM<sup>−1</sup>. Furthermore, the fabricated sensor shows high sensitivity, good selectivity, and good stability toward theophylline determination. Finally, we used the prepared electrode as an actual sample to the determination of theophylline in pharmaceutical formulations.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Highly sensitive detection of theophylline by differential pulse voltammetry using zinc oxide nanoparticles and multiwalled carbon nanotubes-modified carbon paste electrode\",\"authors\":\"Yuanzheng Zhu, Yuedie Zhang, Xinyu Hao, Qiang Xia, Shuping Zhang\",\"doi\":\"10.1007/s11696-024-03557-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Theophylline is a kind of methyl xanthine derivative that can be found in various foods and is a widely used bronchodilator drug. It is significant to detect theophylline by a sensitive, low-cost, and rapid determination technique. In the investigation, zinc oxide (ZnO) nanoparticles and multiwalled carbon nanotubes (MWCNTs) co-modified carbon paste electrode (CPE) was fabricated by a simple procedure and then was successfully applied to determine theophylline. The electrochemical behavior of the modified electrode was explored using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Compared with the bare CPE and MWCNTs/CPE, the ZnO-modified MWCNTs/CPE electrode (ZnO/MWCNTs/CPE) exhibited good promoting effect on the electrochemical reaction of theophylline. Under the optimized experimental statuses, the differential pulse voltammetric peak currents can be used to detect TP, since it had a linear relationship with the theophylline concentration in the range of 3.3 × 10<sup>−7</sup>–1.3 × 10<sup>−4</sup> M. The detection limit is 8.3 × 10<sup>−8</sup> M (<i>S/N</i> = 3), and the sensitivity is 0.12048 μA μM<sup>−1</sup>. Furthermore, the fabricated sensor shows high sensitivity, good selectivity, and good stability toward theophylline determination. Finally, we used the prepared electrode as an actual sample to the determination of theophylline in pharmaceutical formulations.</p></div>\",\"PeriodicalId\":513,\"journal\":{\"name\":\"Chemical Papers\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-08-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Papers\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11696-024-03557-5\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Engineering\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Papers","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11696-024-03557-5","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Engineering","Score":null,"Total":0}
Highly sensitive detection of theophylline by differential pulse voltammetry using zinc oxide nanoparticles and multiwalled carbon nanotubes-modified carbon paste electrode
Theophylline is a kind of methyl xanthine derivative that can be found in various foods and is a widely used bronchodilator drug. It is significant to detect theophylline by a sensitive, low-cost, and rapid determination technique. In the investigation, zinc oxide (ZnO) nanoparticles and multiwalled carbon nanotubes (MWCNTs) co-modified carbon paste electrode (CPE) was fabricated by a simple procedure and then was successfully applied to determine theophylline. The electrochemical behavior of the modified electrode was explored using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Compared with the bare CPE and MWCNTs/CPE, the ZnO-modified MWCNTs/CPE electrode (ZnO/MWCNTs/CPE) exhibited good promoting effect on the electrochemical reaction of theophylline. Under the optimized experimental statuses, the differential pulse voltammetric peak currents can be used to detect TP, since it had a linear relationship with the theophylline concentration in the range of 3.3 × 10−7–1.3 × 10−4 M. The detection limit is 8.3 × 10−8 M (S/N = 3), and the sensitivity is 0.12048 μA μM−1. Furthermore, the fabricated sensor shows high sensitivity, good selectivity, and good stability toward theophylline determination. Finally, we used the prepared electrode as an actual sample to the determination of theophylline in pharmaceutical formulations.
Chemical PapersChemical Engineering-General Chemical Engineering
CiteScore
3.30
自引率
4.50%
发文量
590
期刊介绍:
Chemical Papers is a peer-reviewed, international journal devoted to basic and applied chemical research. It has a broad scope covering the chemical sciences, but favors interdisciplinary research and studies that bring chemistry together with other disciplines.