冻土层岩石中的芽孢杆菌属微生物代谢物对 T 淋巴细胞分化的影响

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-12 DOI:10.1007/s10517-024-06212-x

S. A. Petrov, Yu. G. Sukovey, L. F. Kalenova, E. G. Kostolomova, A. M. Subbotin, M. V. Narushko, A. S. Bazhin

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引用次数: 0

摘要

我们研究了在不同温度培养条件下获得的冻土微生物代谢物对调节性（Treg）和效应 T 淋巴细胞分化活性的影响。研究发现，代谢物的影响在很大程度上受其类型的调节，而类型则取决于生产温度（"低温 "为 5°C，"中温 "为 22°C，"高温 "为 37°C）。所研究的代谢物会影响 Tregs（CD4+CD25hiCD127-）的分化以及 CD4+ 和 CD8+ T 淋巴细胞早期（CD69）、中期（CD25）和晚期（HLA DR）活化标志物的表达。在 "冷 "代谢物的情况下，Treg 水平的增加与 CD4+ T 淋巴细胞分化强度的降低有关，而在 "暖 "代谢物的影响下，则与 CD8+ T 淋巴细胞分化活性的降低有关。在 "中温 "代谢物的影响下，Tregs 对 CD4+ 和 CD8+ T 淋巴细胞分化强度的影响大致相同。

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The Influence of Metabolites of Microorganisms of the Genus Bacillus from Permafrost Rocks on T Lymphocyte Differentiation

We studied the influence of metabolites of permafrost microorganisms obtained at different temperature incubation conditions on activity of differentiation of regulatory (Treg) and effector T lymphocytes. It was found that the effect of metabolites is largely regulated by their type that depends on the temperature of production (“cold” at 5°C, “medium temperature” at 22°C, and “warm” at 37°C). The studied metabolites influenced the differentiation of Tregs (CD4⁺CD25^hiCD127^—) and the expression of markers of early (CD69), middle (CD25), and late (HLA DR) activation of CD4⁺ and CD8⁺ T lymphocytes. In the case of “cold” metabolites, the increase in Treg levels was associated with a decrease in the intensity of CD4⁺ T lymphocyte differentiation, and under the influence of “warm” metabolites — with a decrease in the activity of CD8⁺ T lymphocyte differentiation. Under the influence of “medium-temperature” metabolites, Tregs had approximately the same effect on the intensity of CD4⁺ and CD8⁺ T lymphocyte differentiation.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.