诊断由热二态真菌引起的人类地方性真菌病:从经典方法到分子方法

IF 4.2 2区 生物学 Q2 MICROBIOLOGY
Joaquina María García-Martín, Antonio Muro, Pedro Fernández-Soto
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引用次数: 0

摘要

人类地方性真菌病是由多种真菌引起的可能致命的疾病,这些真菌会随着温度的升高而改变形态。这些温度二态真菌既影响健康的宿主,也影响免疫力低下的宿主,造成巨大的健康和经济负担。尽管如此,地方性真菌病的诊断仍然是一项艰巨的挑战,原因包括症状相似、传统诊断方法的效用有限、大多数地方性真菌病流行地区无法获得可靠的分子方法以及这些地区缺乏临床怀疑。本综述总结了有关热二态真菌及其引发的危及生命的疾病的基本知识。此外,还介绍了传统诊断方法的原理、优势和局限性,以及替代诊断策略的应用现状和未来发展方向,这将有助于减轻地方病流行地区的疾病负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diagnosis of Human Endemic Mycoses Caused by Thermally Dimorphic Fungi: From Classical to Molecular Methods
Human endemic mycoses are potentially fatal diseases caused by a diverse group of fungi that can alter their morphology in response to an increase in temperature. These thermally dimorphic fungi affect both healthy and immunocompromised hosts, causing a substantial health and economic burden. Despite this, the diagnosis of endemic mycoses is still a formidable challenge for several reasons, including similar symptomatology, limited utility of classical diagnostic methods, inaccessibility to reliable molecular approaches in most endemic areas, and a lack of clinical suspicion out of these regions. This review summarizes essential knowledge on thermally dimorphic fungi and the life-threatening diseases they cause. The principle, advantages and limitations of the methods traditionally used for their diagnosis are also described, along with the application status and future directions for the development of alternative diagnostic strategies, which could help to reduce the disease burden in endemic areas.
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来源期刊
Journal of Fungi
Journal of Fungi Medicine-Microbiology (medical)
CiteScore
6.70
自引率
14.90%
发文量
1151
审稿时长
11 weeks
期刊介绍: Journal of Fungi (ISSN 2309-608X) is an international, peer-reviewed scientific open access journal that provides an advanced forum for studies related to pathogenic fungi, fungal biology, and all other aspects of fungal research. The journal publishes reviews, regular research papers, and communications in quarterly issues. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on paper length. Full experimental details must be provided so that the results can be reproduced.
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