中国中老年人高密度脂蛋白胆固醇水平升高前的认知障碍和抑郁:跨滞后面板分析

IF 3.9 2区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Yi-Hui Liu, Mu-Tong Chen, Yong-Yi He, Ming Chen, Jia-Rong Liang, Fu-Jun Jia, Quan Huang, Rui Zhou, Cai-Lan Hou
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引用次数: 0

摘要

高密度脂蛋白胆固醇(HDL-C)对认知能力下降的保护作用已得到广泛认可。然而,最近的研究结果却相互矛盾,一些研究表明高密度脂蛋白胆固醇水平对认知能力没有明显的益处,甚至会增加患痴呆症的风险。对于抑郁症患者来说,高密度脂蛋白胆固醇对认知能力的益处可能会被削弱或逆转。本研究旨在调查中国中老年人高密度脂蛋白胆固醇、认知能力和抑郁症状之间的关联。所使用的数据集来自中国健康与退休纵向研究(CHARLS)2011年和2015年的数据,共有4302名参与者。研究采用了交叉滞后模型来探讨认知表现与高密度脂蛋白胆固醇水平之间的时序关系,并研究抑郁、认知和高密度脂蛋白胆固醇之间的相互作用。社会人口特征、睡眠状况和慢性病史等干扰因素均已得到控制。分析表明,基线认知障碍和抑郁严重程度对随访时高密度脂蛋白胆固醇水平的增加具有单向影响(β = - 0.036 和 β = 0.028,P 0.05)。研究发现,抑郁症状与认知有显著的双向联系(β = - 0.026 和 β = - 0.053,P < 0.05)。认知障碍和抑郁与较高的高密度脂蛋白胆固醇水平有关,而较高的高密度脂蛋白胆固醇水平似乎并不能防止认知功能下降或抑郁症状。这些发现强调了保护认知和心理健康的重要性,因为这可以降低罹患心血管疾病和痴呆症的可能性。未来的研究应验证这些发现,并针对特定人群制定有针对性的干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cognitive impairment and depression precede increased HDL-C levels in middle-aged and older Chinese adults: cross-lagged panel analyses
High-density lipoprotein cholesterol (HDL-C) is widely recognized for its protective effects against cognitive decline. However, recent studies have presented conflicting results, with some suggesting no significant cognitive benefits or even an increased risk of dementia associated with high HDL-C levels. For those who suffer from depression, the cognitive benefits of HDL-C may be diminished or reversed. The purpose of this study is to investigate the associations between HDL-C, cognitive ability, and depressive symptoms in middle-aged and older Chinese adults. The datasets utilized were sourced from the China Health and Retirement Longitudinal Study (CHARLS) for the years 2011 and 2015, comprising 4,302 participants. Cross-lagged models were employed to explore the temporal sequence between cognitive performance and HDL-C levels, and to examine the interplay among depression, cognition, and HDL-C. Confounding factors such as sociodemographic characteristics, sleep conditions, and history of chronic diseases were controlled for. The analysis revealed unidirectional effects of baseline impaired cognition and greater severity of depression on increased HDL-C levels at follow-up (β = − 0.036 and β = 0.028, respectively, P < 0.05). However, higher baseline HDL-C levels did not significantly predict cognitive performance or depression 4 years later (β = − 0.008 and β = 0.023, respectively, P > 0.05). Depressive symptoms and cognition were found to have a significant bidirectional association (β = − 0.026 and β = − 0.053, respectively, P < 0.05). Cognitive impairment and depression are associated with higher HDL-C levels, whereas higher HDL-C levels do not appear to protect against cognitive decline or depressive symptoms. These findings underscore the importance of preserving cognitive and mental health, which may lower the likelihood of cardiovascular disease and dementia. Future studies should validate these findings and develop targeted interventions tailored to specific populations.
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来源期刊
Lipids in Health and Disease
Lipids in Health and Disease 生物-生化与分子生物学
CiteScore
7.70
自引率
2.20%
发文量
122
审稿时长
3-8 weeks
期刊介绍: Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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