偏心肌肉收缩后的细胞内 Ca2+：瑞诺丁受体的关键作用

IF 4.9 2区医学 Q1 PHYSIOLOGY

Exercise and Sport Sciences Reviews Pub Date : 2024-09-05 DOI:10.1249/jes.0000000000000348

Ayaka Tabuchi,David C Poole,Yutaka Kano

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引用次数: 0

摘要

偏心收缩（ECC）会导致细胞内钙离子（Ca2+）过度积累，并在肌纤维的局部区域造成肌肉结构损伤。在这项研究中，我们提出了一个新的假设，即雷诺丁受体（RyR）在唤起 Ca2+ 动力学特征方面起着核心作用，这种特征与其他肌肉适应性反应明显不同。

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Intracellular Ca2+ After Eccentric Muscle Contractions: Key Role for Ryanodine Receptors.

Eccentric contractions (ECC) induce excessive intracellular calcium ion (Ca2+) accumulation and muscle structural damage in localized regions of the muscle fibers. In this investigation, we present the novel hypothesis that the ryanodine receptor (RyR) plays a central role in evoking a Ca2+ dynamics profile that is markedly distinguishable from other muscle adaptive responses.

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来源期刊

Exercise and Sport Sciences Reviews 社会科学-生理学

CiteScore

10.70

自引率

1.80%

发文量

期刊介绍： Exercise and Sport Sciences Reviews made the transition from an annual hardcover series book to a quarterly journal in January 2000. The mission of this American College of Sports Medicine publication is to provide premier quarterly reviews of the most contemporary scientific, medical, and research-based topics emerging in the field of sports medicine and exercise science. The publication strives to provide the most relevant, topical information to students, professors, clinicians, scientists, and professionals for practical and research applications.