Ziyun Luo, Yong Li, Minjuan Xie, Song Yi, Shizhang Xu, Jun Luo
{"title":"可溶性抑制肿瘤生成 2 与 STEMI 患者造影剂诱发的急性肾损伤有关","authors":"Ziyun Luo, Yong Li, Minjuan Xie, Song Yi, Shizhang Xu, Jun Luo","doi":"10.1007/s11255-024-04204-4","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Contrast-induced acute kidney injury (CI-AKI) is a common complication after percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). Soluble suppression of tumorigenicity 2 (sST2) is associated with AKI. However, the relationship between sST2 and CI-AKI is unclear. This study aimed to investigate the relationship between sST2 and CI-AKI in patients with STEMI.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This was a single-center retrospective observational study. Patients diagnosed with STEMI in the Yichun People’s Hospital from February 2020 to May 2024 were continuously included. CI-AKI was defined as an increase in serum creatinine of at least 50% or 0.3 mg/dL from baseline within 48–72 h after contrast exposure.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The incidence of CI-AKI after PCI was 12.4% (98/791). Univariate analysis showed that age, fasting plasma glucose, diabetes mellitus, Killip class, left ventricular ejection fraction, estimated glomerular filtration rate, high sensitivity troponin T, N-terminal pro-B-type natriuretic peptide, and sST2 were associated with CI-AKI. The above factors were included in a multivariate analysis, which showed that sST2 was an independent factor for CI-AKI after PCI. The restricted cubic splines showed a nonlinear dose–response relationship between sST2 and CI-AKI (<i>P</i> < 0.001). The integration of the sST2 could significantly improve the ability of the model to identify CI-AKI (NRI 0.681, 95% CI 0.474–0.887; IDI 0.063, 95% CI 0.038–0.099).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Elevated sST2 is an independent risk factor for CI-AKI after PCI in patients with STEMI. Integration of sST2 can significantly improve the risk model for CI-AKI.</p>","PeriodicalId":14454,"journal":{"name":"International Urology and Nephrology","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Soluble suppression of tumorigenicity 2 associated with contrast-induced acute kidney injury in patients with STEMI\",\"authors\":\"Ziyun Luo, Yong Li, Minjuan Xie, Song Yi, Shizhang Xu, Jun Luo\",\"doi\":\"10.1007/s11255-024-04204-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Background</h3><p>Contrast-induced acute kidney injury (CI-AKI) is a common complication after percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). Soluble suppression of tumorigenicity 2 (sST2) is associated with AKI. However, the relationship between sST2 and CI-AKI is unclear. This study aimed to investigate the relationship between sST2 and CI-AKI in patients with STEMI.</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>This was a single-center retrospective observational study. Patients diagnosed with STEMI in the Yichun People’s Hospital from February 2020 to May 2024 were continuously included. CI-AKI was defined as an increase in serum creatinine of at least 50% or 0.3 mg/dL from baseline within 48–72 h after contrast exposure.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>The incidence of CI-AKI after PCI was 12.4% (98/791). Univariate analysis showed that age, fasting plasma glucose, diabetes mellitus, Killip class, left ventricular ejection fraction, estimated glomerular filtration rate, high sensitivity troponin T, N-terminal pro-B-type natriuretic peptide, and sST2 were associated with CI-AKI. The above factors were included in a multivariate analysis, which showed that sST2 was an independent factor for CI-AKI after PCI. The restricted cubic splines showed a nonlinear dose–response relationship between sST2 and CI-AKI (<i>P</i> < 0.001). The integration of the sST2 could significantly improve the ability of the model to identify CI-AKI (NRI 0.681, 95% CI 0.474–0.887; IDI 0.063, 95% CI 0.038–0.099).</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusion</h3><p>Elevated sST2 is an independent risk factor for CI-AKI after PCI in patients with STEMI. 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Soluble suppression of tumorigenicity 2 associated with contrast-induced acute kidney injury in patients with STEMI
Background
Contrast-induced acute kidney injury (CI-AKI) is a common complication after percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). Soluble suppression of tumorigenicity 2 (sST2) is associated with AKI. However, the relationship between sST2 and CI-AKI is unclear. This study aimed to investigate the relationship between sST2 and CI-AKI in patients with STEMI.
Methods
This was a single-center retrospective observational study. Patients diagnosed with STEMI in the Yichun People’s Hospital from February 2020 to May 2024 were continuously included. CI-AKI was defined as an increase in serum creatinine of at least 50% or 0.3 mg/dL from baseline within 48–72 h after contrast exposure.
Results
The incidence of CI-AKI after PCI was 12.4% (98/791). Univariate analysis showed that age, fasting plasma glucose, diabetes mellitus, Killip class, left ventricular ejection fraction, estimated glomerular filtration rate, high sensitivity troponin T, N-terminal pro-B-type natriuretic peptide, and sST2 were associated with CI-AKI. The above factors were included in a multivariate analysis, which showed that sST2 was an independent factor for CI-AKI after PCI. The restricted cubic splines showed a nonlinear dose–response relationship between sST2 and CI-AKI (P < 0.001). The integration of the sST2 could significantly improve the ability of the model to identify CI-AKI (NRI 0.681, 95% CI 0.474–0.887; IDI 0.063, 95% CI 0.038–0.099).
Conclusion
Elevated sST2 is an independent risk factor for CI-AKI after PCI in patients with STEMI. Integration of sST2 can significantly improve the risk model for CI-AKI.
期刊介绍:
International Urology and Nephrology publishes original papers on a broad range of topics in urology, nephrology and andrology. The journal integrates papers originating from clinical practice.