99m锝-半乳糖基人血清白蛋白(99m锝-GSA)血池 SUV 分析与血容量归一化用于预测严重肝衰竭患者的短期存活率:初步报告

IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Naoya Yama, Hiroomi Tatsumi, Masayuki Akatsuka, Masamitsu Hatakenaka
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引用次数: 0

摘要

目的 本研究评估了99m锝-半乳糖基人血清白蛋白(99m锝-GSA)闪烁扫描的SUV分析(包括按血容量归一化的心血池SUV分析)作为重症肝功能衰竭患者短期存活率预测指标的实用性。患者和方法 我们纳入了24例接受99m锝-GSA闪烁扫描并入住重症监护室的重症肝功能衰竭患者。在进行99m锝-GSA闪烁扫描后的7天、14天和28天,患者被分为存活组和非存活组。我们根据SPECT图像计算心脏血池的SUV值,并根据体重、瘦体重、日本瘦体重和血容量进行归一化处理;我们还计算肝脏的SUV值,并根据体重、瘦体重和日本瘦体重进行归一化处理。我们还根据 99mTc-GSA 闪烁图的平面图像计算了 15 分钟时心脏摄取量与 3 分钟时心脏摄取量之比(HH15)以及 15 分钟时肝脏摄取量与 15 分钟时肝脏加心脏摄取量之比(LHL15)。结果7天存活组和非存活组在心脏和肝脏的所有SUV值以及HH15方面存在显著差异,14天存活组的心脏SUV值按日本瘦体重和血容量归一化后存在显著差异,28天存活组在任何SUV值、HH15或LHL15方面均无显著差异。结论99m锝-GSA的SUV分析(包括按血容量归一化的心脏血池SUV分析)对预测重症肝衰竭病例的短期生存率有价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Blood-pool SUV analysis of 99mTc-galactosyl human serum albumin (99mTc-GSA) normalized by blood volume for prediction of short-term survival in severe liver failure: preliminary report

Blood-pool SUV analysis of 99mTc-galactosyl human serum albumin (99mTc-GSA) normalized by blood volume for prediction of short-term survival in severe liver failure: preliminary report

Purpose

This study evaluated the usefulness of SUV analysis of 99mTc-galactosyl human serum albumin (99mTc-GSA) scintigraphy including SUV analysis of the cardiac blood pool normalized by blood volume as a predictor of short-term survival in severe liver failure.

Patients and methods

We enrolled 24 patients with severe liver failure who underwent 99mTc-GSA scintigraphy and were admitted to the intensive care unit. Patients were divided into survival and non-survival groups at 7, 14, and 28 days from the performance of 99mTc-GSA scintigraphy. From SPECT images we calculated SUVs of the cardiac blood pool, performing normalization for body weight, lean body weight, Japanese lean body weight, and blood volume and we calculated SUVs of the liver, normalizing by body weight, lean body weight, and Japanese lean body weight. We also calculated the uptake ratio of the heart at 15 min to that at 3 min (HH15) and the uptake ratio of the liver at 15 min to the liver plus the heart at 15 min (LHL15) from planar images of 99mTc-GSA scintigraphy.

Results

There were significant differences between the 7 day survival and non-survival groups for all SUVs of the heart and the liver and HH15, for 14 day survival groups in SUVs of the heart normalized by Japanese lean body weight and blood volume, and no significant differences between 28 day survival groups for any SUVs, HH15, or LHL15. Although the difference was not significant, SUV analysis of the heart normalized by blood volume showed the highest value for the area under the receiver-operating-characteristics curve for both 7 day and 14 day survival.

Conclusion

SUV analysis of 99mTc-GSA including SUV analysis of cardiac blood pool normalized by blood volume is of value for prediction of short-term survival in cases with severe liver failure.

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来源期刊
Annals of Nuclear Medicine
Annals of Nuclear Medicine 医学-核医学
CiteScore
4.90
自引率
7.70%
发文量
111
审稿时长
4-8 weeks
期刊介绍: Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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