脊柱转移手术后早期死亡率的术前预测。

IF 1.9 4区 医学 Q3 ONCOLOGY
Hiroto Kamoda,Toshinori Tsukanishi,Hideyuki Kinoshita,Yoko Hagiwara,Yuji Endo,Hiroki Takahashi,Kosuke Takeda,Tetsuya Hirashima,Takeshi Ishii,Tsukasa Yonemoto
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引用次数: 0

摘要

材料与方法这项回顾性研究纳入了 2009 年至 2021 年期间在我院接受脊柱转移手术的患者。收集所有患者的术前血液检测数据,并通过除以血液数据计算生存时间。结果研究对象包括 83 名患者(平均 64.5 岁),其中 22 人在 3 个月内死亡。最常见的病变部位是胸椎,57名患者出现不完全瘫痪。手术方法包括后路植入固定术(17 例)、后路减压术(31 例)和后路减压加固定术(35 例)。在单变量分析中,术前六项采血指标(血红蛋白、C 反应蛋白、白蛋白、白细胞、γ-谷氨酰转肽酶和乳酸脱氢酶)的异常值与术后存活率显著相关。在多变量分析中,四个检测项目(血红蛋白、C反应蛋白、白细胞和乳酸脱氢酶)被确定为独立的预后因素。将上述四个项目中异常值≥3个的病例(高危组,n = 23)与异常值≤2个的病例(低危组,n = 60)进行比较,生存时间有显著差异。结论该研究表明,术前血液检测的四项异常(血红蛋白、C 反应蛋白白细胞和乳酸脱氢酶)预示着术后 3 个月内早期死亡的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preoperative prediction of early mortality after surgery for spinal metastases.
OBJECTIVE The objective of this study was to provide a convenient preoperative prediction of the risk of early postoperative mortality. MATERIALS AND METHODS This retrospective study included patients who underwent surgery for spinal metastasis at our hospital between 2009 and 2021. Preoperative blood test data of all patients were collected, and the survival time was calculated by dividing the blood data. A multivariate analysis was conducted using a Cox proportional hazards model to identify prognostic factors. RESULTS The study population included 83 patients (average: 64.5 years), 22 of whom died within 3 months. The most common lesion was the thoracic spine, and incomplete paralysis was observed in 57 patients. The surgical methods included posterior implant fixation (n = 17), posterior decompression (n = 31), and posterior decompression with fixation (n = 35). In the univariate analysis, the presence of abnormal values was significantly associated with postoperative survival in six preoperative blood collection items (hemoglobin, C-reactive protein, albumin, white blood cell, gamma-glutamyl transpeptidase, and lactate dehydrogenase). In a multivariate analysis, four test items (hemoglobin, C-reactive protein, white blood cell, and lactate dehydrogenase) were identified as independent prognostic factors.Comparing cases with ≥3 abnormal values among the above four items (high-risk group; n = 23) and those with ≤2 (low-risk group; n = 60), there was a significant difference in survival time. In addition, it was possible to predict cases of early death within 3 months after surgery with 73% sensitivity and 89% specificity. CONCLUSIONS The study showed that four preoperative blood test abnormalities (hemoglobin, C-reactive protein white blood cell, and lactate dehydrogenase) indicated the possibility of early death within 3 months after surgery.
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来源期刊
CiteScore
3.70
自引率
8.30%
发文量
177
审稿时长
3-8 weeks
期刊介绍: Japanese Journal of Clinical Oncology is a multidisciplinary journal for clinical oncologists which strives to publish high quality manuscripts addressing medical oncology, clinical trials, radiology, surgery, basic research, and palliative care. The journal aims to contribute to the world"s scientific community with special attention to the area of clinical oncology and the Asian region. JJCO publishes various articles types including: ・Original Articles ・Case Reports ・Clinical Trial Notes ・Cancer Genetics Reports ・Epidemiology Notes ・Technical Notes ・Short Communications ・Letters to the Editors ・Solicited Reviews
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