一种时间可控的 2-芳基咪唑并[1,2-a]吡啶的选择性溴化和甲酰化反应

IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Sheiva Iranfar, Morteza Shiri, Soma Majedi, Arezoo Madankan, Seyyed Emad Hooshmand, Gul Bahar Alizadeh, Ahmed Al-Harrasi
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引用次数: 0

摘要

在时间可控的条件下,利用二甲基亚砜和溴化铜(II),设计出了一种意想不到的选择性合成技术,用于合成 3-溴-2-芳基咪唑并[1,2-a]吡啶和 3-甲酰基-2-芳基咪唑并[1,2-a]吡啶衍生物。首先对咪唑并吡啶进行溴化,然后将溴化的咪唑并吡啶转化为甲酰化的咪唑并吡啶。与以往的技术相比,这项创新技术具有多种优势,例如可按顺序合成溴化和甲酰化咪唑并[1,2-a]吡啶,还首次同时利用 CuBr2 和 DMSO 作为双重活性剂。此外,这一实用工艺还能生产两种在医疗和制药领域广泛使用的产品,从而提高了其效率和适应性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A time-controlled selective bromination and formylation of 2-arylimidazo[1,2-a]pyridines

A time-controlled selective bromination and formylation of 2-arylimidazo[1,2-a]pyridines

An unexpected and selective synthetic technique was devised for 3-bromo-2-arylimidazo[1,2-a]pyridine and 3-formyl-2-arylimidazo[1,2-a]pyridine derivatives synthesis, utilizing DMSO and copper(II) bromide under time-controlled settings. Initially, the imidazopyridines underwent bromination, followed by the subsequent conversion of the brominated imidazopyridines into formylated imidazopyridines. This innovative technique has various advantages over previous ones, such as sequential synthesis of brominated and formylated imidazo[1,2-a]pyridines and, for the first time, utilizing CuBr2 and DMSO as dual active agents simultaneously. This practical process can moreover produce two widely used products in the medical and pharmaceutical realm which increases its efficiency and adaptability.

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来源期刊
CiteScore
4.40
自引率
8.30%
发文量
230
审稿时长
5.6 months
期刊介绍: JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.
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