{"title":"开发并验证一种适应不同文化的事件相关电位范式,用于评估酒精依赖症患者的酒精线索反应性和错误处理能力","authors":"Anupa Arunkumar Shenoy, Samir Kumar Praharaj, Shweta Rai, Kirtana R. Nayak, Arun Sasidharan, Hari Prakash Palaniswamy, Chinmay Ajit Suryavanshi, Sumit Sharma, Umesh Shreekantiah, Vrinda Marigowda","doi":"10.1177/02537176241266879","DOIUrl":null,"url":null,"abstract":"Background:Research on event-related potentials (ERP) in addiction highlights the importance of cognitive ERP markers, such as P300 and error-related negativity (ERN), in distinguishing between alcohol-dependent patients and healthy controls. We aimed to develop and validate ERP paradigms utilizing culturally validated stimuli to evoke P300 and ERN for the Indian population.Methods:In a cross-sectional study, 16 alcohol-dependent patients and age-matched healthy controls were recruited. For P300, we designed a visual oddball (Go/No-Go) task using culturally appropriate alcohol and non-alcohol-related images. To study ERN, we used the Assessing Neurocognition via Gamified Experimental Logic (ANGEL) task, developed in India, integrating its “game” levels to capture error monitoring with fewer trials. A 32-channel EEG-ERP system was used for data acquisition.Results:Participants showed high engagement in the visual Go/No-Go task, with 94.4% accuracy. The P300 difference wave showed significantly higher amplitudes ( p = .01, Cohen’s d = 0.97) and latencies ( p < .001, Cohen’s d = 1.62) in patients compared to controls at the Pz electrode. No significant group differences were found in accuracy or reaction times for frequent and rare stimuli. In the ANGEL task, patients had a significantly lower ERN difference wave amplitude at the Pz electrode than controls ( p < .001, Cohen’s d = 1.47), with no latency differences. Task accuracy was lower, and reaction time was longer in patients.Conclusions:The visual Go/No-Go task and the ANGEL task are promising tools for understanding the neurocognitive mechanisms underlying alcohol dependence in the Indian context.","PeriodicalId":13476,"journal":{"name":"Indian Journal of Psychological Medicine","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Development and Validation of a Culturally Adapted, Event-related Potential Paradigm for Assessing Alcohol Cue Reactivity and Error Processing in Alcohol Dependence\",\"authors\":\"Anupa Arunkumar Shenoy, Samir Kumar Praharaj, Shweta Rai, Kirtana R. Nayak, Arun Sasidharan, Hari Prakash Palaniswamy, Chinmay Ajit Suryavanshi, Sumit Sharma, Umesh Shreekantiah, Vrinda Marigowda\",\"doi\":\"10.1177/02537176241266879\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background:Research on event-related potentials (ERP) in addiction highlights the importance of cognitive ERP markers, such as P300 and error-related negativity (ERN), in distinguishing between alcohol-dependent patients and healthy controls. We aimed to develop and validate ERP paradigms utilizing culturally validated stimuli to evoke P300 and ERN for the Indian population.Methods:In a cross-sectional study, 16 alcohol-dependent patients and age-matched healthy controls were recruited. For P300, we designed a visual oddball (Go/No-Go) task using culturally appropriate alcohol and non-alcohol-related images. To study ERN, we used the Assessing Neurocognition via Gamified Experimental Logic (ANGEL) task, developed in India, integrating its “game” levels to capture error monitoring with fewer trials. A 32-channel EEG-ERP system was used for data acquisition.Results:Participants showed high engagement in the visual Go/No-Go task, with 94.4% accuracy. The P300 difference wave showed significantly higher amplitudes ( p = .01, Cohen’s d = 0.97) and latencies ( p < .001, Cohen’s d = 1.62) in patients compared to controls at the Pz electrode. No significant group differences were found in accuracy or reaction times for frequent and rare stimuli. In the ANGEL task, patients had a significantly lower ERN difference wave amplitude at the Pz electrode than controls ( p < .001, Cohen’s d = 1.47), with no latency differences. Task accuracy was lower, and reaction time was longer in patients.Conclusions:The visual Go/No-Go task and the ANGEL task are promising tools for understanding the neurocognitive mechanisms underlying alcohol dependence in the Indian context.\",\"PeriodicalId\":13476,\"journal\":{\"name\":\"Indian Journal of Psychological Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-08-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Psychological Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/02537176241266879\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Psychological Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/02537176241266879","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Development and Validation of a Culturally Adapted, Event-related Potential Paradigm for Assessing Alcohol Cue Reactivity and Error Processing in Alcohol Dependence
Background:Research on event-related potentials (ERP) in addiction highlights the importance of cognitive ERP markers, such as P300 and error-related negativity (ERN), in distinguishing between alcohol-dependent patients and healthy controls. We aimed to develop and validate ERP paradigms utilizing culturally validated stimuli to evoke P300 and ERN for the Indian population.Methods:In a cross-sectional study, 16 alcohol-dependent patients and age-matched healthy controls were recruited. For P300, we designed a visual oddball (Go/No-Go) task using culturally appropriate alcohol and non-alcohol-related images. To study ERN, we used the Assessing Neurocognition via Gamified Experimental Logic (ANGEL) task, developed in India, integrating its “game” levels to capture error monitoring with fewer trials. A 32-channel EEG-ERP system was used for data acquisition.Results:Participants showed high engagement in the visual Go/No-Go task, with 94.4% accuracy. The P300 difference wave showed significantly higher amplitudes ( p = .01, Cohen’s d = 0.97) and latencies ( p < .001, Cohen’s d = 1.62) in patients compared to controls at the Pz electrode. No significant group differences were found in accuracy or reaction times for frequent and rare stimuli. In the ANGEL task, patients had a significantly lower ERN difference wave amplitude at the Pz electrode than controls ( p < .001, Cohen’s d = 1.47), with no latency differences. Task accuracy was lower, and reaction time was longer in patients.Conclusions:The visual Go/No-Go task and the ANGEL task are promising tools for understanding the neurocognitive mechanisms underlying alcohol dependence in the Indian context.
期刊介绍:
The Indian Journal of Psychological Medicine (ISSN 0253-7176) was started in 1978 as the official publication of the Indian Psychiatric Society South Zonal Branch. The journal allows free access (Open Access) and is published Bimonthly. The Journal includes but is not limited to review articles, original research, opinions, and letters. The Editor and publisher accept no legal responsibility for any opinions, omissions or errors by the authors, nor do they approve of any product advertised within the journal.