利用超声定位显微镜恢复血管:最小方差波束形成器与延迟和波束形成器的模拟比较研究

IF 3.8 2区 物理与天体物理 Q1 ACOUSTICS
Vasiliki Voulgaridou , Barbara Nicolas , Steven McDougall , Lachlan Arthur , Georgios Papageorgiou , Mairead Butler , Evangelos Kanoulas , Konstantinos Diamantis , Weiping Lu , Vassilis Sboros
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引用次数: 0

摘要

在对比增强超声(CEUS)或其他包含稀疏微泡(MB)群的超声模式图像数据上使用粒子定位和跟踪算法,可以生成超分辨血管图。这类数据通常来自超声成像模式中广泛使用的传统延迟和(DAS)波束成形。最近,自适应波束成形技术在空间分辨率方面有了显著提高,但其对超分辨图像分析方法的价值还没有得到充分认识。本研究评估了结合最小方差波束成形器(MV BF)的性能,与单粒子检测的 DAS BF 相比,MV BF 可提高横向分辨率。研究考虑了一系列简化的图像影响因素(如流动轮廓、脉冲长度、噪声、血管分离度和数据可用性)的单独影响。研究旨在评估使用不同波束形成器的容器恢复性能,并调查与 MB 检测和定位之间的联系。结果表明,与传统的 DAS BF 相比,MV BF 的微血管定位精度更高。特别是,血管分离度在 0.3-4 λ 之间时,MV 可提供更好的定位不确定性。此外,对于 0.36 λ 的分离度,两种方法都能实现血管恢复,但使用 MV 消除了作为附加血管出现的伪影。研究发现,这些结果与中压 BF 改善了 MB 检测和定位有关,建议在超声定位显微镜 (ULM) 成像中使用患者数据进行测试。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vessel recovery using ultrasound localisation microscopy: An in silico comparative study between minimum variance and delay-and-sum beamformers

The use of particle localisation and tracking algorithms on Contrast Enhanced Ultrasound (CEUS) or other ultrasound mode image data containing sparse microbubble (MB) populations, can produce super-resolved vascularization maps. Typically such data stem from conventional delay and sum (DAS) beamforming that is used widely in ultrasound imaging modes. Recently, adaptive beamforming has shown significant improvement in spatial resolution, but its value to super-resolution image analysis approaches is not fully understood. The in silico study here evaluates the performance of combining minimum variance beamformers (MV BF), established to provide improved lateral resolution, compared to DAS BFs with single particle detection. The isolated effect of a range of simplified image-affecting factors such as flow profile, pulse length, noise, vessel separations and data availability is considered. The study aims to assess the vessel recovery performance using the different beamformers and investigate the link with MB detection and localisation. The MV BF was shown to provide improved microvessel position accuracy compared to conventional DAS BFs. In particular, vessel separations between 0.3–4 λ provided superior localisation uncertainty with the MV. In addition, for a separation of 0.36λ, vessel recovery was achieved with both methods but the use of MV eliminated artifacts that appear as additional vessels. These results were found to be linked to improved MB detection and localisation for the MV BF, which is proposed as suitable for testing in Ultrasound Localisation Microscopy (ULM) imaging using patient data.

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来源期刊
Ultrasonics
Ultrasonics 医学-核医学
CiteScore
7.60
自引率
19.00%
发文量
186
审稿时长
3.9 months
期刊介绍: Ultrasonics is the only internationally established journal which covers the entire field of ultrasound research and technology and all its many applications. Ultrasonics contains a variety of sections to keep readers fully informed and up-to-date on the whole spectrum of research and development throughout the world. Ultrasonics publishes papers of exceptional quality and of relevance to both academia and industry. Manuscripts in which ultrasonics is a central issue and not simply an incidental tool or minor issue, are welcomed. As well as top quality original research papers and review articles by world renowned experts, Ultrasonics also regularly features short communications, a calendar of forthcoming events and special issues dedicated to topical subjects.
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