用于子宫支架的可生物降解锌-0.8锂-0.4镁合金的体外研究

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Letters Pub Date : 2024-09-11 DOI:10.1016/j.matlet.2024.137373

Guo Bao , Jialing He , Nan Li , Changyong Zhang , Tianqi Wang , Yufeng Zheng

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引用次数: 0

摘要

子宫支架植入术是治疗人类宫内粘连的有效方法。目前的临床干预措施，如铜宫内节育器或聚合物球囊，存在炎症反应和需要二次手术等局限性。因此，研究用于子宫修复的可生物降解支架至关重要。我们研究了 Zn-0.8Li-0.4 Mg 合金在子宫微环境中的降解行为及其与子宫内膜上皮细胞的相容性。在 Zn-0.8Li-0.4 Mg 合金中观察到了 Li₂CO3 的形成。在 SUF 中，Zn-0.8Li-0.4 Mg 合金的体外降解率为 1.29 × 10-2 mm/年。Zn-0.8Li-0.4 Mg 合金提取液中的 Zn2+ 浓度为 12.94 ± 1.80 mg/L，明显低于 Zn 的浓度（16.73 ± 2.93 mg/L）。此外，Zn-0.8Li-0.4 Mg 合金中的 Li+ 浓度为 1.35 ± 0.34 mg/L。该合金与在 50% 浸出液中培养的 HEECs 以及在 Zn-0.8Li-0.4 Mg 合金表面培养的 HEECs 具有良好的兼容性，这表明它具有宫内应用的潜力。

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In vitro studies of biodegradable Zn-0.8Li-0.4 Mg alloy for uterine stent application

Uterine stent implantation is an effective treatment for human intrauterine adhesion. Current clinical interventions, such as Cu-IUD or polymer balloons, have limitations including inflammatory responses and the need for a second operation. Thus, investigating a biodegradable scaffold for uterine repair is crucial. We studied the degradation behavior of the Zn-0.8Li-0.4 Mg alloy in the uterine microenvironment and its compatibility with endometrial epithelial cells. The formation of Li₂CO₃ was observed in Zn-0.8Li-0.4 Mg alloy. The in vitro degradation rates of Zn-0.8Li-0.4 Mg alloy were 1.29 × 10^-2 mm/year in SUF. The Zn²⁺ concentration in the extract solution for the Zn-0.8Li-0.4 Mg alloy was 12.94 ± 1.80 mg/L, significantly lower than that of Zn, which was 16.73 ± 2.93 mg/L. Additionally, the Li⁺ concentration in the Zn-0.8Li-0.4 Mg alloy was 1.35 ± 0.34 mg/L. The alloy exhibited good compatibility with HEECs cultured in a 50 % leaching solution and culture on the surface of the Zn-0.8Li-0.4 Mg alloy, suggesting its potential for intrauterine applications.

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来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive